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Naomi R. Latorraca
Researcher at Stanford University
Publications - 37
Citations - 3875
Naomi R. Latorraca is an academic researcher from Stanford University. The author has contributed to research in topics: G protein-coupled receptor & G protein. The author has an hindex of 22, co-authored 33 publications receiving 2511 citations. Previous affiliations of Naomi R. Latorraca include University of California, Berkeley & University of Pittsburgh.
Papers
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Journal ArticleDOI
GPCR Dynamics: Structures in Motion
TL;DR: What is currently known about the flexibility and dynamics of GPCRs, as determined through crystallography, spectroscopy, and computer simulations is reviewed.
Journal ArticleDOI
Structure of the µ-opioid receptor–G i protein complex
Antoine Koehl,Hongli Hu,Shoji Maeda,Yan Zhang,Qianhui Qu,Joseph M. Paggi,Naomi R. Latorraca,Daniel Hilger,Roger J. P. Dawson,Hugues Matile,Gebhard F. X. Schertler,Gebhard F. X. Schertler,Sébastien Granier,William I. Weis,Ron O. Dror,Aashish Manglik,Georgios Skiniotis,Brian K. Kobilka +17 more
TL;DR: In this article, a 3.5-dimensional structure of the μ-opioid receptor (μOR) bound to the agonist peptide DAMGO and nucleotide-free Gi was determined.
Journal ArticleDOI
Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors
X. Edward Zhou,X. Edward Zhou,Yuanzheng He,Parker W. de Waal,Xiang Gao,Yanyong Kang,Ned Van Eps,Yanting Yin,Yanting Yin,Kuntal Pal,Devrishi Goswami,Thomas A. White,Anton Barty,Naomi R. Latorraca,Henry N. Chapman,Wayne L. Hubbell,Ron O. Dror,Raymond C. Stevens,Raymond C. Stevens,Vadim Cherezov,Vsevolod V. Gurevich,Patrick R. Griffin,Oliver P. Ernst,Karsten Melcher,H. Eric Xu,H. Eric Xu +25 more
TL;DR: An X-ray free electron laser (XFEL) crystal structure of the rhodopsin-arrestin complex is reported, in which the phosphorylated C terminus of r Rhodopsin forms an extended intermolecular β sheet with the N-terminal β strands of arrestin.
Journal ArticleDOI
Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex
Kaavya Krishna Kumar,Moran Shalev-Benami,Michael J. Robertson,Hongli Hu,Samuel D. Banister,Scott A. Hollingsworth,Naomi R. Latorraca,Hideaki E. Kato,Daniel Hilger,Shoji Maeda,William I. Weis,William I. Weis,David L. Farrens,Ron O. Dror,Sanjay V. Malhotra,Brian K. Kobilka,Georgios Skiniotis,Georgios Skiniotis +17 more
TL;DR: The structure of the CB1-Gi signaling complex bound to the highly potent agonist MDMB-Fubinaca (FUB) is presented, which compose the structural framework to explain CB1 activation by different classes of ligands and provide insights into the G protein coupling and selectivity mechanisms adopted by the receptor.
Journal ArticleDOI
Structure of the M2 Muscarinic Receptor-β-Arrestin Complex in a Lipid Nanodisc
Dean P. Staus,Dean P. Staus,Hongli Hu,Hongli Hu,Michael J. Robertson,Alissa L. W. Kleinhenz,Alissa L. W. Kleinhenz,Alissa L. W. Kleinhenz,Laura M. Wingler,Laura M. Wingler,William D. Capel,Naomi R. Latorraca,Robert J. Lefkowitz,Robert J. Lefkowitz,Georgios Skiniotis +14 more
TL;DR: A cryo-electron microscopy structure of β-arrestin 1 in complex with M2 muscarinic receptor reconstituted in lipid nanodiscs is presented and it is shown that the C-edge is critical for stable complex formation, βarr1 recruitment, receptor internalization, and desensitization of G-protein activation.