R
Roger L. Waite
Researcher at Charles Stark Draper Laboratory
Publications - 56
Citations - 1715
Roger L. Waite is an academic researcher from Charles Stark Draper Laboratory. The author has contributed to research in topics: Addiction & Dopaminergic. The author has an hindex of 20, co-authored 56 publications receiving 1562 citations.
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Journal ArticleDOI
Attention-Deficit-Hyperactivity Disorder and Reward Deficiency Syndrome
Kenneth Blum,Amanda Lih Chuan Chen,Eric R. Braverman,David E. Comings,Thomas J H Chen,Vanessa Arcuri,Seth H. Blum,Bernard W. Downs,Roger L. Waite,Alison Notaro,Joel F. Lubar,Lonna Williams,Thomas J. Prihoda,Tomás Palomo,Marlene Oscar-Berman +14 more
TL;DR: It is concluded that dopamine and serotonin releasers might be useful therapeutic adjuncts for the treatment of other RDS behavioral subtypes, including addictions.
Journal ArticleDOI
Activation instead of blocking mesolimbic dopaminergic reward circuitry is a preferred modality in the long term treatment of reward deficiency syndrome (RDS): a commentary.
Kenneth Blum,Amanda Lih Chuan Chen,Thomas J H Chen,Eric R Braverman,Jeffrey Reinking,Seth H. Blum,Kimberly Cassel,Bernard W. Downs,Roger L. Waite,Lonna Williams,Thomas J. Prihoda,Mallory Kerner,Tomás Palomo,David E. Comings,Howard Tung,Patrick Rhoades,Marlene Oscar-Berman +16 more
TL;DR: D2 receptor stimulation can be accomplished via the use of Synapatmine™, a natural but therapeutic nutraceutical formulation that potentially induces DA release, causing the same induction of D 2-directed mRNA and thus proliferation of D2 receptors in the human, which will induce the attenuation of craving behavior.
Journal ArticleDOI
Overcoming qEEG abnormalities and reward gene deficits during protracted abstinence in male psychostimulant and polydrug abusers utilizing putative dopamine D₂ agonist therapy: part 2.
Kenneth Blum,Thomas J H Chen,Siobhan Morse,John Giordano,Amanda Lih Chaun Chen,James E. Thompson,Cameron Allen,Andrew Smolen,Joel F. Lubar,Eric Stice,B. William Downs,Roger L. Waite,Margaret A. Madigan,Mallory Kerner,Frank Fornari,Eric R Braverman +15 more
TL;DR: This seminal work is proposing that with necessary large populations supporting these initial results, and possibly even additional candidate genes and single nucleotide polymorphisms, the authors may eventually have the clinical ability to classify severity according to genotype and possession of risk alleles, along with offering a safe, nonaddicting, natural dopaminergic receptor agonist.
Journal ArticleDOI
Generational Association Studies of Dopaminergic Genes in Reward Deficiency Syndrome (RDS) Subjects: Selecting Appropriate Phenotypes for Reward Dependence Behaviors
Kenneth Blum,Amanda L C Chen,Marlene Oscar-Berman,Thomas J H Chen,Joel F. Lubar,Nancy White,Judith O. Lubar,Abdalla Bowirrat,Eric R. Braverman,John Schoolfield,Roger L. Waite,Bernard W. Downs,Margaret A. Madigan,David E. Comings,Caroline Davis,Mallory Kerner,Jennifer Knopf,Tomás Palomo,John Giordano,Siobhan Morse,Frank Fornari,Debmalya Barh,John Femino,John A. Bailey +23 more
TL;DR: The results support the putative role of dopaminergic polymorphisms in RDS behaviors and shows the importance of a nonspecific RDS phenotype and informs an understanding of how evaluating single subset behaviors of RDS may lead to spurious results.
Journal Article
Dopamine D2 receptor Taq A1 allele predicts treatment compliance of LG839 in a subset analysis of pilot study in the Netherlands
Kenneth Blum,Thomas J H Chen,Amanda L C Chen,Patrick Rhoades,Thomas J. Prihoda,B. William Downs,Debasis Bagchi,Manashi Bagchi,Seth H. Blum,Lonna Williams,Eric R. Braverman,Mallory Kerner,Roger L. Waite,Brien Quirk,Lisa D. White,Jeffrey Reinking +15 more
TL;DR: This research presents a novel and scalable approach to personalized medicine that combines natural selection, cell reprograming, and data collection and annotation for the first time to solve the mystery of why some people are obese and others are not.