R
Rogier M. Bertina
Researcher at Leiden University Medical Center
Publications - 231
Citations - 25196
Rogier M. Bertina is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Factor V Leiden & Venous thrombosis. The author has an hindex of 69, co-authored 231 publications receiving 24436 citations. Previous affiliations of Rogier M. Bertina include Leiden University & Loyola University Medical Center.
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Journal ArticleDOI
Mutation in blood coagulation factor V associated with resistance to activated protein C
Rogier M. Bertina,Bobby P. C. Koeleman,Ted Koster,Frits R. Rosendaal,Richard J. Dirven,Hans De Ronde,Pieter A. van der Velden,Pieter H. Reitsma +7 more
TL;DR: It is demonstrated that the phenotype of APC resistance is associated with hetero-zygosity or homozygosity for a single point mutation in the factor V gene which predicts the synthesis of a factor V molecule that is not properly inactivated by APC.
Journal ArticleDOI
A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.
TL;DR: An association was found between the presence of the 20210 A allele and elevated prothrombin levels and Elevated pro thirdrombin itself also was found to be a risk factor for venous thrombosis.
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Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study
Ted Koster,Jan P. Vandenbroucke,Frits R. Rosendaal,H de Ronde,Ernest Briët,Rogier M. Bertina +5 more
TL;DR: It is concluded that the poor response to APC is the most important hereditary cause of venous thrombosis, and its high prevalence in a series of unselected patients will make testing of all thromBosis patients for this abnormality worth while.
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Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor v leiden mutation
Jan P. Vandenbroucke,Ted Koster,E. Briët,Pieter H. Reitsma,Rogier M. Bertina,Frits R. Rosendaal +5 more
TL;DR: Recalculation of population incidences shows that the absolute risk of venous thrombosis in young women who use oral contraceptives is much larger when they carry the factor V Leiden mutation.
Journal ArticleDOI
High levels of coagulation factor XI as a risk factor for venous thrombosis.
Joost C. M. Meijers,Winnie L.H. Tekelenburg,Bonno N. Bouma,Rogier M. Bertina,Frits R. Rosendaal +4 more
TL;DR: High levels of factor XI are a risk factor for deep venous thrombosis, with a doubling of the risk at levels that are present in 10 percent of the population.