Rohinton Edalji

TL;DR: The results demonstrate the feasibility of using small molecule inhibitors to selectively target the catalytic activity of histone acetyltransferases, which may provide effective treatments for transcriptional activator-driven malignancies and diseases.

TL;DR: Using NMR, the NMR data indicate that soluble oligomers of Abeta preglobulomer and globulomer have a mixed parallel and antiparallel beta-sheet structure that is different from fibrils which contain only parallel beta-sheets.

TL;DR: The structural information derived in this study together with the known structure/activity relationships for CsA analogues may prove useful in the design of improved immunosuppressants and the approach described for obtaining the structural information is widely applicable to the study of small molecule/large molecule interactions.

TL;DR: It is shown that a bridge is formed across the polyphosphate binding site between the two β chains demonstrating that the cross-link stabilizes the deoxy conformation but does not prevent the conformational change associated with oxygenation.

TL;DR: The binding of a 13C-labeled cyclosporin A (CsA) analog to cyclophilin was examined by means of isotope-edited nuclear magnetic resonance (NMR) techniques, and nuclear Overhauser effects were observed between the zeta 3 and epsilon 3 protons of the methylleucine (MeLeu) residue at position 9 of CsA.