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Roland Buhl
Researcher at University of Mainz
Publications - 413
Citations - 17237
Roland Buhl is an academic researcher from University of Mainz. The author has contributed to research in topics: Asthma & COPD. The author has an hindex of 64, co-authored 375 publications receiving 14927 citations.
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Journal ArticleDOI
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial.
Ian D. Pavord,Stephanie Korn,Peter H. Howarth,Eugene R. Bleecker,Roland Buhl,Oliver N. Keene,Hector Ortega,Pascal Chanez +7 more
TL;DR: Mepolizumab is an effective and well tolerated treatment that reduces the risk of asthma exacerbations in patients with severe eosinophilic asthma.
Journal ArticleDOI
High-Dose Acetylcysteine in Idiopathic Pulmonary Fibrosis
Maurits Demedts,Juergen Behr,Roland Buhl,Ulrich Costabel,Richard Dekhuijzen,Henk M. Jansen,William MacNee,Michiel Thomeer,Benoit Wallaert,François Laurent,Andrew G. Nicholson,Eric Verbeken,Johny Verschakelen,Christopher D.R. Flower,Frédérique Capron,Stefano Petruzzelli,Paul De Vuyst,Jules M.M. van den Bosch,Eulogio Rodriguez-Becerra,Giuseppina Corvasce,Ida Lankhorst,Marco Sardina,Mauro Montanari +22 more
TL;DR: Therapy with acetylcysteine at a dose of 600 mg three times daily, added to prednisone and azathioprine, preserves vital capacity and DL(CO) in patients with idiopathic pulmonary fibrosis better than does standard therapy alone.
Journal ArticleDOI
The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma
Jean Bousquet,P. Cabrera,Neville Berkman,Roland Buhl,Stephen T. Holgate,Sally E. Wenzel,Howard Fox,S. Hedgecock,M. Blogg,G. Della Cioppa +9 more
TL;DR: Patients with severe persistent asthma who are inadequately controlled despite treatment according to current asthma management guidelines have a significant unmet medical need and are at high risk of serious exacerbations and asthma‐related mortality.
Journal ArticleDOI
Systemic deficiency of glutathione in cystic fibrosis.
TL;DR: It is hypothesized that glutathione in respiratory epithelial lining fluid (ELF) in CF patients might be oxidized and/or diminished in amount compared with that in normal subjects and observed marked neutrophil-dominated inflammation in ELF inCF patients.
Journal ArticleDOI
Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases
Oliver Pfaar,Claus Bachert,Albrecht Bufe,Roland Buhl,Christof Ebner,Peter Eng,Frank Friedrichs,Thomas Fuchs,Eckard Hamelmann,Doris Hartwig-Bade,Thomas Hering,Isidor Huttegger,Kirsten Jung,Ludger Klimek,Matthias V. Kopp,Hans F. Merk,Uta Rabe,Joachim Saloga,Peter Schmid-Grendelmeier,Antje Schuster,Nicolaus Schwerk,Helmut Sitter,Ulrich Umpfenbach,Bettina Wedi,Stefan Wöhrl,Margitta Worm,Jörg Kleine-Tebbe +26 more
TL;DR: Meta-analyses provide unequivocal evidence of the efficacy of SCIT and SLIT for certain allergen sources and age groups and require product-specific evaluation.