Economic Control of Quality of Manufactured Product.

The modification of mammalian membrane polyunsaturated fatty acid composition in relation to membrane fluidity and function

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

The serum creatinine concentration is widely interpreted as a measure of the glomerular filtration rate (GFR) and is used as an index of renal function in clinical practice. Glomerular filtration of creatinine, however, is only one of the variables that determines its concentration in serum. Alterations in renal handling and metabolism of creatinine and methodological interferences in its measurement may have a profound impact on the serum concentration of creatinine. We review the fundamental principles of physiology, metabolism, and analytical chemistry that are necessary to correctly interpret the serum creatinine concentration. These principles are then applied to important clinical circumstances, including aging, pregnancy, diabetes mellitus, drug administration, and acute and chronic renal failure. Despite numerous limitations, serum creatinine remains a useful clinical tool, but more accurate measures of renal function are frequently necessary.

Serum creatinine as an index of renal function: new insights into old concepts.

Quantitative Effects of Dietary Fat on Serum Cholesterol in Man

The influence of dietary fats on serum-lipid levels in man.

β-carotene-15, 151-14C, β-carotene-15, 151-3H, vitamin A alcohol-15-14C, and vitamin A-15-3H acetate were fed to eight patients in whom polyethylene cannulae had been inserted in the thoracic duct in the neck. The lymph lipids were extracted and chromatographed on columns and on thin-layer plates of alumina. Only 8.7-16.8 per cent of the fed labelled β-carotene is normally absorbed via the lymphatic pathway and mainly recovered as retinyl esters. Unchanged labelled β-carotene comprised only 1.7 to 27.9 per cent of the radioactivity after ingestion of labelled β-carotene.The recovery of the radioactivity in the lymph lipids after feeding labelled vitamin A alcohol or acetate was in the range of 6.7 to 66.9 per cent. Absorption of radioactivity into the lymph followed the appearance of the chylomicron triglycerides.Labelled retinyl esters, mainly retinyl palmitate, represented 75 to 90 per cent of the absorbed radioactivity after feeding labelled vitamin A, and 60 to 75 per cent after feeding labelled β-car...

Studies on the intestinal absorption of radioactive β-carotene and vitamin A in man. Conversion of β-carotene into vitamin A.

Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazole

Serum cholesterol determination by mass fragmentography

Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model

Rolf Blomstrand

Papers

The influence of dietary fats on serum-lipid levels in man.

Studies on the intestinal absorption of radioactive β-carotene and vitamin A in man. Conversion of β-carotene into vitamin A.

Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazole

Serum cholesterol determination by mass fragmentography

Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model