U
Ute I. Schwarz
Researcher at University of Western Ontario
Publications - 62
Citations - 6245
Ute I. Schwarz is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Population & Warfarin. The author has an hindex of 28, co-authored 58 publications receiving 5919 citations. Previous affiliations of Ute I. Schwarz include Vanderbilt University Medical Center & Vanderbilt University.
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Journal ArticleDOI
Identification of functionally variant MDR1 alleles among European Americans and African Americans
Richard B. Kim,Richard B. Kim,Brenda F. Leake,Brenda F. Leake,Edna F. Choo,Edna F. Choo,George K. Dresser,George K. Dresser,Samir V. Kubba,Samir V. Kubba,Ute I. Schwarz,Ute I. Schwarz,Amanda Taylor,Amanda Taylor,H. G. Xie,H. G. Xie,Joel McKinsey,Joel McKinsey,Sheng Zhou,Sheng Zhou,Lu-Bin Lan,Lu-Bin Lan,John D. Schuetz,John D. Schuetz,Erin G. Schuetz,Erin G. Schuetz,Grant R. Wilkinson,Grant R. Wilkinson +27 more
TL;DR: Allelic variation in MDR1 is more common than previously recognized and involves multiple SNPs whose allelic frequencies vary between populations, and some of these SNPs are associated with altered P‐glycoprotein function.
Journal ArticleDOI
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine.
George K. Dresser,George K. Dresser,George K. Dresser,D. G. Bailey,D. G. Bailey,D. G. Bailey,Brenda F. Leake,Brenda F. Leake,Brenda F. Leake,Ute I. Schwarz,Ute I. Schwarz,Ute I. Schwarz,Paul A. Dawson,Paul A. Dawson,Paul A. Dawson,David J. Freeman,David J. Freeman,David J. Freeman,Richard B. Kim,Richard B. Kim,Richard B. Kim +20 more
TL;DR: The objective was to examine the effect of different fruits and their constituents on P‐glycoprotein and organic anion transporting polypeptide activities in vitro and on drug disposition in humans.
Journal ArticleDOI
Genetic determinants of response to warfarin during initial anticoagulation.
Ute I. Schwarz,Marylyn D. Ritchie,Yuki Bradford,Chun Li,Scott M. Dudek,Amy Frye-Anderson,Richard B. Kim,Dan M. Roden,C. Michael Stein +8 more
TL;DR: Initial variability in the INR response to warfarin was more strongly associated with genetic variability inThe pharmacologic target of warfarIn, VKORC1, than with CYP2C9, and both of these genotypes had a significant influence on the required warfarins after the first 2 weeks of therapy.
Journal ArticleDOI
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
Gregory M. Cooper,Julie A. Johnson,Taimour Y. Langaee,Hua Feng,Ian B. Stanaway,Ute I. Schwarz,Marylyn D. Ritchie,C. Michael Stein,Dan M. Roden,Joshua D. Smith,David L. Veenstra,Allan E. Rettie,Mark J. Rieder +12 more
TL;DR: It is concluded that common SNPs with large effects on warfarin dose are unlikely to be discovered outside of the CYP2C9 and VKORC1 genes and Randomized clinical trials that account for these 2 genes should produce results that are definitive and broadly applicable.
Journal ArticleDOI
Intestinal drug transporter expression and the impact of grapefruit juice in humans.
Hartmut Glaeser,Hartmut Glaeser,David G. Bailey,David G. Bailey,G K Dresser,J C Gregor,Ute I. Schwarz,Ute I. Schwarz,J S McGrath,E Jolicoeur,Wooin Lee,Brenda F. Leake,Rommel G. Tirona,Rommel G. Tirona,Rommel G. Tirona,Richard B. Kim,Richard B. Kim +16 more
TL;DR: OATP1A2 is likely the key intestinal uptake transporter for fexofenadine absorption whose inhibition results in the grapefruit juice effect, and an array of drug uptake and efflux transporters are expressed in the human intestine.