R
Ronald H. Schwartz
Researcher at National Institutes of Health
Publications - 211
Citations - 26552
Ronald H. Schwartz is an academic researcher from National Institutes of Health. The author has contributed to research in topics: T cell & Antigen. The author has an hindex of 79, co-authored 211 publications receiving 26135 citations.
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A cell culture model for T lymphocyte clonal anergy
TL;DR: The T cell enters an unresponsive state known as clonal anergy in which the T cell is incapable of producing its own growth hormone, interleukin-2, on restimulation.
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Clonal Expansion Versus Functional Clonal Inactivation: A Costimulatory Signalling Pathway Determines the Outcome of T Cell Antigen Receptor Occupancy
TL;DR: Etude du controle de la proliferation des lymphocytes T par les cellules presentant l'antigene, examen des signaux biologiques and biochimiques impliques dans ce mecanisme.
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T cell anergy
TL;DR: T cell anergy is a tolerance mechanism in which the lymphocyte is intrinsically functionally inactivated following an antigen encounter, but remains alive for an extended period of time in a hyporesponsive state as discussed by the authors.
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Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
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Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo.
TL;DR: The results suggest that nonmitogenic T cell recognition of antigen/MHC on ECDI-modified APCs results in the functional inactivation of T cell clones.