R
Ronald J. Holewinski
Researcher at Cedars-Sinai Medical Center
Publications - 39
Citations - 1113
Ronald J. Holewinski is an academic researcher from Cedars-Sinai Medical Center. The author has contributed to research in topics: Phosphorylation & Heart failure. The author has an hindex of 16, co-authored 36 publications receiving 825 citations. Previous affiliations of Ronald J. Holewinski include Johns Hopkins University School of Medicine & Johns Hopkins University.
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Journal ArticleDOI
Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease
Dong I. Lee,Guangshuo Zhu,Takashi Sasaki,Gun Sik Cho,Nazha Hamdani,Ronald J. Holewinski,Su Hyun Jo,Thomas Danner,Manling Zhang,Peter P. Rainer,Djahida Bedja,Jonathan A. Kirk,Mark J. Ranek,Wolfgang R. Dostmann,Chulan Kwon,Kenneth B. Margulies,Jennifer E. Van Eyk,Walter Paulus,Eiki Takimoto,David A. Kass +19 more
TL;DR: It is shown that cGMP-selective PDE9A is expressed in the mammalian heart, including humans, and is upregulated by hypertrophy and cardiac failure, and its role in stress-induced heart disease suggests potential as a therapeutic target.
Journal ArticleDOI
PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress
Mark J. Ranek,Kristen M. Kokkonen-Simon,Anna Chen,Brittany Dunkerly-Eyring,Miguel Pinilla Vera,Christian U. Oeing,Chirag H. Patel,Taishi Nakamura,Guangshuo Zhu,Djahida Bedja,Masayuki Sasaki,Ronald J. Holewinski,Jennifer E. Van Eyk,Jonathan D. Powell,Dong Ik Lee,David A. Kass +15 more
TL;DR: It is shown that phosphorylation or gain- or loss-of-function mutations at either of two adjacent serine residues in TSC2 can bidirectionally control mTORC1 activity stimulated by growth factors or haemodynamic stress, and consequently modulate cell growth and autophagy.
Journal ArticleDOI
Cardiac resynchronization sensitizes the sarcomere to calcium by reactivating GSK-3β
Jonathan A. Kirk,Ronald J. Holewinski,Viola Kooij,Giulio Agnetti,Richard S. Tunin,Namthip Witayavanitkul,Pieter P. de Tombe,Wei Dong Gao,Jennifer E. Van Eyk,David A. Kass +9 more
TL;DR: Data indicate that CRT improves calcium responsiveness of myofilaments following HF(dys) through GSK-3β reactivation, identifying a therapeutic approach to enhancing contractile function.
Journal ArticleDOI
Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1.
John W. Bullen,Irina Tchernyshyov,Ronald J. Holewinski,Lauren R. DeVine,Fan Wu,Vidya Venkatraman,D. Kass,Robert N. Cole,Jennifer E. Van Eyk,Gregg L. Semenza +9 more
TL;DR: In this article, protein kinase A (PKA) was shown to activate the transcription of genes encoding proteins that enable cells to adapt to reduced O 2 availability, which contributes to the pathophysiology of cancer and heart disease.
Journal ArticleDOI
Characterization of the cardiac myosin binding protein-C phosphoproteome in healthy and failing human hearts
TL;DR: The most highly phosphorylated site on cMyBP-C was Ser284 and this site showed decreased phosphorylation in the failing heart, which implicates importance for fine-tuning contractility.