R
Ronald J. Voll
Researcher at Emory University
Publications - 70
Citations - 1190
Ronald J. Voll is an academic researcher from Emory University. The author has contributed to research in topics: Dopamine transporter & Serotonin transporter. The author has an hindex of 19, co-authored 68 publications receiving 1115 citations. Previous affiliations of Ronald J. Voll include Yerkes National Primate Research Center.
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Journal ArticleDOI
Synthesis, F-18 radiolabeling, and microPET evaluation of 3-(2,4-dichlorophenyl)-N-alkyl-N-fluoroalkyl-2,5-dimethylpyrazolo[1,5-a]pyrimidin-7-amines as ligands of the corticotropin-releasing factor type-1 (CRF1) receptor.
Jeffrey S. Stehouwer,Matthew S. Birnbaum,Ronald J. Voll,Michael J. Owens,Susan J Plott,Chase H. Bourke,Michael A. Wassef,Clinton D. Kilts,Mark M. Goodman +8 more
TL;DR: Brain penetrance in an anesthetized male cynomolgus monkey demonstrated brain penetrance, but specific binding was not sufficient enough to differentiate regions of high CRF1 receptor density from regions of low CRF 1 receptor density.
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A benzenesulfonamide derivative as a novel PET radioligand for CXCR4.
Yoon Hyeun Oum,Dinesh K. Shetty,Younghyoun Yoon,Zhongxing Liang,Ronald J. Voll,Mark M. Goodman,Hyunsuk Shim +6 more
TL;DR: A novel small molecule CXCR4-targeted PET agent (compound 5) is developed by combining the established benzenesulfonamide scaffold with a labeling component by virtue of click chemistry, demonstrating a competitive cellular uptake against CXCL12 in a dose-dependent manner.
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Synthesis, binding affinity, radiolabeling, and microPET evaluation of 4-(2-substituted-4-substituted)-8-(dialkylamino)-6-methyl-1-substituted-3,4-dihydropyrido[2,3-b]pyrazin-2(1H)-ones as ligands for brain corticotropin-releasing factor type-1 (CRF1) receptors.
Jeffrey S. Stehouwer,Chase H. Bourke,Michael J. Owens,Ronald J. Voll,Clinton D. Kilts,Mark M. Goodman +5 more
TL;DR: Compounds 1-14 were synthesized in a search for high-affinity CRF1 receptor ligands that could be radiolabeled with (11)C or (18)F for use as positron emission tomography (PET) radiotracers but microPET imaging with [( 18)F]25 demonstrated limited brain uptake.
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Stereospecificity of the fructose 2,6-bisphosphate site of muscle 6-phosphofructo-1-kinase.
TL;DR: Findings indicate that, unlike its active site, this allosteric site of 6-phosphofructo-1-kinase does not require the furanose ring, and its basic requirement seems to be a compound with two phosphate groups approximately 9 A apart.
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Synthesis of 2‐[11C]methoxy‐3,17β‐estradiol to measure the pharmacokinetics of an antitumor drug candidate, 2‐methoxy‐3,17β‐estradiol
TL;DR: 2-Methoxy-3,17β-estradiol, an endogenous estrogen metabolite, showed cytotoxicity in various cancer cell lines and also has antiangiogenic and proapoptotic activities, was synthesized from a precursor in two steps with over 99% radiochemical purity.