Ronald J. Voll

TL;DR: Substitution at the 4'-position of the dimethylated and monomethylated benzylamines differently influenced SERT binding, and alkyl, alkenyl, or hydroxymethyl functions at the 3'-position afford compounds with high SERT affinity, and omega-hydroxy and fluoro-substituted ethyl and propyl groups at the4'-position decrease the SERT preference.

TL;DR: In vitro competition binding assays demonstrated that compounds 9-12 have a high affinity for the DAT and are selective for theDAT compared to the serotonin and norepinephrine transporters.

TL;DR: The findings indicate that adolescence in female rhesus monkeys is a period of central 5HT reorganization, partly influenced by exposure to the social stress of subordination, that likely functions to integrate adrenal and gonadal systems and shape the behavioral response to emotionally challenging social situations.

TL;DR: Compound L-368,899 was successfully alkylated with [(11)C]iodomethane to generate the oxytocin receptor selective (2R)-2-amino-N-((2S)-7,7-dimethyl-1-(((4-(o-tolyl)piperazin- 1-yl)sulfonyl)methyl) methyl)bicyclo) with very high radiochemical purity and high specific activity.

TL;DR: In vivo bindings of N, N-dimethyl-2-(2'-amino-4'-hydroxymethyl-phenylthio)-5-bromobenzylamine, substituted on ring A, were shown to be specific to the SERT as displacement with citalopram (a potent SERT ligand) reduced radioactivity in SERT-rich regions to the cerebellum level.