Showing papers by "Ronald Klein published in 2022"

TL;DR: In this article , the retromer core protein VPS35 is depleted in hippocampal neurons, and then the protein is replete using an optimized viral vector protocol to strengthen the causal link between the neuronal retromers and AD-associated neuronal phenotypes, including acceleration of amyloid precursor protein cleavage and the loss of synaptic glutamate receptors.