Yasir H. Qureshi

TL;DR: This study uses a Systems Biology approach to reverse engineer the transcriptional regulation layer of human neuronal cells and interrogate it to infer candidate Master Regulators responsible for disease progression, and suggests that an integrative, SB approach can be applied to AD and other neurodegenerative diseases, and provide significant novel insight on the disease progression.

TL;DR: Converging data suggest that promoting autophagic degradation, either by inducing autophagosome formation or enhancing lysosomal digestion, provides viable therapeutic strategies for AD therapeutic interventions.

TL;DR: This study suggests that EGFR tyrosine kinase mutation and ALK translocation results in improved survival to targeted therapies and that mutation status itself does not predict survival and local control in patients with brain metastases from NSCLC.

TL;DR: The initial experience with robotic-enhanced percutaneous coronary intervention was not associated with increased fluoroscopy duration, radiation, or contrast media exposure to patients, and compared favorably to the traditional approach.

TL;DR: The AD-associated CLN5 variant is shown here to reduce the normal processing of cathepsin D and to decrease levels of full-length amyloid precursor protein (APP), suggestive of a defect in retromer-dependent trafficking.