R
Ronald M. Lindsay
Researcher at Regeneron
Publications - 173
Citations - 26407
Ronald M. Lindsay is an academic researcher from Regeneron. The author has contributed to research in topics: Neurotrophic factors & Neurotrophin. The author has an hindex of 82, co-authored 171 publications receiving 25872 citations. Previous affiliations of Ronald M. Lindsay include National Institute for Medical Research & Scripps Research Institute.
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Journal ArticleDOI
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra.
Carolyn Hyman,Magdalena Hofer,Yves-Alain Barde,M Juhasz,George D. Yancopoulos,Stephen P. Squinto,Ronald M. Lindsay +6 more
TL;DR: BRAIN-derived neurotrophic factor seems to be a trophic factor for mesencephalic dopaminergic neurons, increasing their survival, including that of neuronal cells which degenerate in Parkinson's disease.
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Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
Maisonpierre Peter C,Leonardo Belluscio,Stephen P. Squinto,Nancy Y. Ip,Mark E. Furth,Ronald M. Lindsay,George D. Yancopoulos +6 more
TL;DR: The distribution of NT-3 messenger RNA and its biological activity on a variety of neuronal populations clearly distinguishNT-3 from NGF and BDNF, and provide compelling evidence that NT- 3 is an authentic neurotrophic factor that has its own characteristic role in vivo.
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NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.
Maisonpierre Peter C,Leonardo Belluscio,Beth Friedman,Ralph F. Alderson,Stanley J. Wiegand,Mark E. Furth,Ronald M. Lindsay,George D. Yancopoulos +7 more
TL;DR: The observations are consistent with the idea that NT-3, BDNF, and NGF have paralleled as well as reciprocal roles in vivo, and do share one striking similarity--high level expression in the adult hippocampus.
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Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons
TL;DR: These results provide the first direct evidence of a continuous dynamic role for NGF in regulation of peptide neurotransmitter/neuromodulator levels in mature sensory neurons.
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Anterograde transport of brain-derived neurotrophic factor and its role in the brain.
C A Altar,Ning Cai,T Bliven,M Juhasz,J M Conner,J M Conner,Ann Acheson,Ronald M. Lindsay,Stanley J. Wiegand +8 more
TL;DR: The number of striatal neurons that contain the calcium-binding protein parvalbumin was decreased in BDNF+/− and BDNF−/− mice in direct proportion to the loss of BDNF protein, which is consistent with anterogradely supplied BDNF having a functional role in development or maintenance.