S
Stephen P. Squinto
Researcher at Regeneron
Publications - 26
Citations - 7778
Stephen P. Squinto is an academic researcher from Regeneron. The author has contributed to research in topics: Neurotrophic factors & Neurotrophin. The author has an hindex of 18, co-authored 25 publications receiving 7588 citations. Previous affiliations of Stephen P. Squinto include Alexion Pharmaceuticals.
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Journal ArticleDOI
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra.
Carolyn Hyman,Magdalena Hofer,Yves-Alain Barde,M Juhasz,George D. Yancopoulos,Stephen P. Squinto,Ronald M. Lindsay +6 more
TL;DR: BRAIN-derived neurotrophic factor seems to be a trophic factor for mesencephalic dopaminergic neurons, increasing their survival, including that of neuronal cells which degenerate in Parkinson's disease.
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Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
Maisonpierre Peter C,Leonardo Belluscio,Stephen P. Squinto,Nancy Y. Ip,Mark E. Furth,Ronald M. Lindsay,George D. Yancopoulos +6 more
TL;DR: The distribution of NT-3 messenger RNA and its biological activity on a variety of neuronal populations clearly distinguishNT-3 from NGF and BDNF, and provide compelling evidence that NT- 3 is an authentic neurotrophic factor that has its own characteristic role in vivo.
Journal ArticleDOI
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor
Stephen P. Squinto,Trevor Stitt,Aldrich Thomas H,Samuel Davis,Stella M. Blanco,Czeslaw Radziejewski,David J. Glass,Piotr Masiakowski,Mark E. Furth,David M. Valenzuela,Peter S. DiStefano,George D. Yancopoulos +11 more
TL;DR: It is demonstrated that all three of these neuronal survival molecules bind similarly to the low affinity NGF receptor, but that BDNF and NT-3, unlike NGF, do not act via the high affinity N GF receptor.
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A BDNF autocrine loop in adult sensory neurons prevents cell death.
Ann Acheson,Joanne C. Conover,James P. Fandl,Thomas M. DeChiara,Michelle Russell,Anu Thadani,Stephen P. Squinto,Stephen P. Squinto,George D. Yancopoulos,Ronald M. Lindsay +9 more
TL;DR: The results strongly suggest an autocrine role for BDNF in mediating the survival of a subpopulation of adult DRG neurons, which could be rescued by exogenous BDNF or neurotrophin-3, but not by other growth factors.
Journal ArticleDOI
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
Nancy Y. Ip,Carlos F. Ibáñez,Steven H. Nye,Joyce McClain,Pamela F. Jones,David R. Gies,Leonardo Belluscio,M M Le Beau,R. Espinosa,Stephen P. Squinto +9 more
TL;DR: A neurotrophin is isolated from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4, which has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophs.