Showing papers in "Neuron in 1990"

TL;DR: This review highlights the importance of identifying the genes that are responsive to trans-synaptic stimulation and membrane electrical activity in neural cells and proposes that IEGs encode regulatory proteins that control the expression of late response genes.

TL;DR: The observations are consistent with the idea that NT-3, BDNF, and NGF have paralleled as well as reciprocal roles in vivo, and do share one striking similarity--high level expression in the adult hippocampus.

TL;DR: The mechanism by which the calcium influx signal is transduced to the nucleus to activate c-fos proto-oncogene transcription has been characterized and CREB can function as a regulatory element that integrates both calcium and cAMP signals in the control of gene expression.

TL;DR: It is proposed that two opposite, adhesive gradients guide circumferential migrations on the epidermis and that the unc-5, unc-6, and unc-40 genes may encode these adhesion molecules or their cellular receptors.

TL;DR: It is concluded that alpha-bungarotoxin binding proteins in the vertebrate nervous system can function as nAChRs.

TL;DR: These immortalized cells will provide an invaluable model system for study of hypothalamic neurosecretory neurons that regulate reproduction and demonstrates the feasibility of immortalizing differentiated neurons by targeting tumorigenesis in transgenic mice to specific neurons of the CNS.

TL;DR: In the rat brain, HDNF mRNA was predominantly found in pyramidal neurons in CA1 and CA2 of the hippocampus, and cells expressing BDNF mRNA were found in the dorsal root ganglia, where neurons of various sizes were labeled.

TL;DR: It is found that a 1000-fold excess of the heterologous ligand is needed to reduce binding to the high-affinity receptor by 50%, but that the same concentrations of BDNF and NGF similarly reduce the binding of either ligand to the low-Affinity receptor.

TL;DR: Brain-derived neurotrophic factor was found to promote the survival of E17 rat embryo septal cholinergic neurons in culture, as assessed by a histochemical stain for acetylcholinesterase (AChE), suggesting that BDNF promotes cell survival and not just induction of AChE.

TL;DR: The use of exo utero surgery to introduce a marker retrovirus into the proliferative zone of the retinas of embryonic day 13 and 14 mice shows that almost all progenitor cells that continued mitosis were multipotential and that a single progenitors can generate most retinal cell types.

TL;DR: The results suggest that no simple relationship exists between LTP, spatial learning, and immediate early gene induction, and that immediate early genes can be differentially activated within the central nervous system.

TL;DR: The GluR5 protein forms homomeric ion channels in Xenopus oocytes that are weakly responsive to L-glutamate and is detected in areas of neuronal differentiation and synapse formation during embryogenesis.

TL;DR: It is demonstrated that basic FGF is a potent mitogen for brain O-2A progenitor cells, but blocks their differentiation into oligodendrocytes, which may modulate the production of myelin-forming cells in the CNS.

TL;DR: The combination alpha 5 beta 2 gamma 2 was identified as the minimal requirement reproducing consensus properties of the vertebrate GABAA receptor channel, including cooperativity of GABA-dependent channel gating with a Ka in the range of 10 microM, modulation by various drugs acting at the benzodiazepine binding site, picrotoxin sensitivity, and barbiturate effects.

TL;DR: Observations indicate that the kainate/quisqualate receptors are encoded by a family of genes and are likely to be composed of hetero-oligomers of at least two distinct subunits.

TL;DR: A novel human protein, designated neuronotrophin-3, has a broad tissue distribution and is structurally related to both nerve growth factor and brain-derived neurotrophic factor, and is likely to play a wide role in defining the fate and function of nerve cells during development.

TL;DR: GABA-gated chloride channels were expressed in human embryonic kidney cells following transfection of cDNAs encoding the alpha 1, beta 2, and gamma 2 subunits of the rat GABAA receptor (GABAR).

TL;DR: An examination of single-channel currents recorded from outside-out patches excised from these transfected cells suggests that despite the common minimal structural requirements for expressing steroid and barbiturate actions, the mechanism of GABAA receptor modulation by these pregnane steroids may differ from that of barbiturates.

TL;DR: C-fos may be a molecular component of the photic pathway for entrainment of mammalian circadian rhythms as well as a circadian pacemaker located in the suprachiasmatic nucleus (SCN) of the mammalian hypothalamus.

TL;DR: A cryptic simplicity underlies the eventual complex structure that develops from this region of the CNS, which contains the first basal plate neurons to develop and the first neuropil.

TL;DR: The molecular nature of the neurotensin receptor is disclosed, which mediates the diverse neuronal and peripheral actions of neurotens in by effecting the G protein-associated second messenger system.

TL;DR: It is shown that cDNA clones encoding alpha BgtBP alpha 1 and alpha 2 subunits definealpha BgtBPs as members of a gene family within the ligand-gated ion channel gene superfamily, but distinct from the gene families of AChRs from muscles and nerves.

TL;DR: Rapid applications of glutamate, quisqualate, and AMPA evoke a transient current in DRG neurons and desensitize cells to subsequent applications of kainate or domoate, which results in half-maximal activation in sensory neurons than in CNS neurons from cerebral cortex.

TL;DR: It is demonstrated that nonneuronal cells in the adult human brain and meninges produce appreciable beta APP695, beta APP751, and beta APP770 mRNA; and changes in beta APP gene expression in the AD brain andmeninges that may contribute to amyloid deposition are identified.

TL;DR: Cross sections of NMJs showed that Ca2+ channels are clustered on the presynaptic membrane adjacent to the postsynaptic membrane, indicating that groups of Ca2- channels are localized exclusively at the active zones of the frog NMJ.

TL;DR: Developmental RNA and histochemical analyses showed parallel onset of transgene and endogenous NSE gene expression in various neuronal cell types, although the magnitude of NSE mRNA accumulation later in development was not matched by the transGene.

TL;DR: The results strongly suggest that FGF or FGF-like molecules may exert effects on specific neuronal populations in the mature CNS.