R
Ronan Bureau
Researcher at University of Caen Lower Normandy
Publications - 102
Citations - 1847
Ronan Bureau is an academic researcher from University of Caen Lower Normandy. The author has contributed to research in topics: Pharmacophore & Virtual screening. The author has an hindex of 24, co-authored 98 publications receiving 1541 citations. Previous affiliations of Ronan Bureau include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Drug repositioning: a brief overview.
TL;DR: Despite some regulatory and economic challenges, drug repositioning offers many advantages, and a number of recent successes have confirmed both its public health benefits and its commercial value.
Journal ArticleDOI
New aromatase inhibitors. Synthesis and biological activity of aryl-substituted pyrrolizine and indolizine derivatives.
Pascal Sonnet,Patrick Dallemagne,Jean Guillon,Cécile Enguehard,Silvia Stiebing,Julien Tanguy,Ronan Bureau,Sylvain Rault,Pierrick Auvray,Safa Moslemi,Pascal Sourdaine,Gilles-Eric Séralini +11 more
TL;DR: The design and the synthesis of some aryl-substituted pyrrolizine and indolizine derivatives are reported, on the basis of a hypothetical pharmacophore structure designed to fit the catalytic site of the human cytochrome P450 aromatase.
Journal ArticleDOI
Toward Safer Thrombolytic Agents in Stroke: Molecular Requirements for NMDA Receptor-Mediated Neurotoxicity
José P. López-Atalaya,Benoit D. Roussel,Benoit D. Roussel,Benoit D. Roussel,Denis Levrat,Jérôme Parcq,Jérôme Parcq,Jérôme Parcq,Olivier Nicole,Olivier Nicole,Yannick Hommet,Yannick Hommet,Yannick Hommet,Karim Benchenane,Karim Benchenane,Karim Benchenane,Hervé Castel,Hervé Castel,Hervé Castel,Jérôme Leprince,Denis To Van,Ronan Bureau,Sylvain Rault,Hubert Vaudry,Karl-Uwe Petersen,Jana Sopkova-de Oliveira Santos,Carine Ali,Carine Ali,Carine Ali,Denis Vivien,Denis Vivien,Denis Vivien +31 more
TL;DR: It is shown that a critical step for interaction of tPA with NR1 is the binding of its K2 domain, followed by thebinding of its catalytic domain, which in turn cleaves the NR1 subunit at its ATD, leading to a subsequent potentiation of NMDA-induced calcium influx and neurotoxicity.
Journal ArticleDOI
Acute toxicity of 8 antidepressants: What are their modes of action?
Laetitia Minguez,Laetitia Minguez,Emilie Farcy,Céline Ballandonne,Alban Lepailleur,Antoine Serpentini,Jean-Marc Lebel,Ronan Bureau,Marie-Pierre Halm-Lemeille +8 more
TL;DR: It is shown by molecular modeling that particular interactions can exist between antidepressants and phosphatidylcholine, a major component of cell membranes, leading to a more specific mode of action corresponding to a potential acidic hydrolysis of ester functions.
Journal ArticleDOI
Hot-Spots of Mcl-1 Protein.
TL;DR: This review focuses on the characterization of the Mcl-1 hot-spots which are related to four hydrophobic pockets P1-P4 and one major electrostatic interaction and analysis of structural data highlights the high importance of the P2/P3 pockets for the binding of non-peptide ligands.