Rong Li

TL;DR: The results not only provide the information for interactions between ERK and STEP, but will also help in the development of specific strategies to target STEP‐ERK recognition, which could serve as a potential therapy for neurological disorders.

TL;DR: This review systematically summarized the relationship between ferroptosis-associated ncRNAs and cancer progression and may provide new ideas for exploring novel diagnostic and therapeutic biomarkers for cancer in the future.

TL;DR: The new chemotypes of Lyp selective inhibitors identified through the target-ligand interaction-based virtual screening method may provide new leads for Lyp targeted therapeutic development.

TL;DR: It is found that PPM1A negatively regulated ERK by directly dephosphorylating its pThr202 position early in EGF stimulation and preferred the phospho‐ERK peptide sequence over a panel of other phosphopeptides through the interactions of basic residues in the active site of P PM1A with the pThR‐Glu‐pTyr motif of ERK.

TL;DR: Knock-out and mutation mouse models show that loss of Vlgr1 function leads to abnormal stereociliary development and hearing loss, indicating crucial roles of V lgr1 in hearing transduction or auditory system development.