Ferroptosis in Cancer Progression: Role of Noncoding RNAs
Ying Zuo,Yinfeng Zhang,Rui Zhang,Jiaxun Tian,Xiaobing Lv,Rong Li,Shu-Ping Li,Meng-Die Cheng,Jing. Shan,Zheng Zhao,Hui Xin +10 more
TLDR
This review systematically summarized the relationship between ferroptosis-associated ncRNAs and cancer progression and may provide new ideas for exploring novel diagnostic and therapeutic biomarkers for cancer in the future.Abstract:
Ferroptosis is a novel form of programmed cell death, and it is characterized by iron-dependent oxidative damage, lipid peroxidation and reactive oxygen species accumulation. Notable studies have revealed that ferroptosis plays vital roles in tumor occurrence and that abundant ferroptosis in cells can inhibit tumor progression. Recently, some noncoding RNAs (ncRNAs), particularly microRNAs, long noncoding RNAs, and circular RNAs, have been shown to be involved in biological processes of ferroptosis, thus affecting cancer growth. However, the definite regulatory mechanism of this phenomenon is still unclear. To clarify this issue, increasing studies have focused on the regulatory roles of ncRNAs in the initiation and development of ferroptosis and the role of ferroptosis in progression of various cancers, such as lung, liver, and breast cancers. In this review, we systematically summarized the relationship between ferroptosis-associated ncRNAs and cancer progression. Moreover, additional evidence is needed to identify the role of ferroptosis-related ncRNAs in cancer progression. This review will help us to understand the roles of ncRNAs in ferroptosis and cancer progression and may provide new ideas for exploring novel diagnostic and therapeutic biomarkers for cancer in the future.read more
Citations
More filters
Journal ArticleDOI
Non-coding RNA in cancer drug resistance: Underlying mechanisms and clinical applications
Xu Zhou,Xiang Ao,Zhaojun Jia,Yiwen Li,Shouxiang Kuang,C. Du,Jin-yu Zhang,Jianxun Wang,Ying Liu +8 more
TL;DR: The recent findings on the emerging role and underlying mechanisms of ncRNAs involved in cancer drug resistance are summarized and their clinical applications as biomarkers and therapeutic targets in cancer treatment are focused on.
Journal ArticleDOI
Ferroptosis, necroptosis, and pyroptosis in the occurrence and development of ovarian cancer
Chunmei Zhang,Ning Liu +1 more
TL;DR: The recent advances in ferroPTosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of OC are summarized.
Journal ArticleDOI
Underlying mechanisms of epithelial splicing regulatory proteins in cancer progression
TL;DR: The information reviewed herein could be extremely beneficial to the development of individualized therapeutic strategies for cancer patients and highlight the clinical implications of ESRPs as prognostic biomarkers and therapeutic targets in cancer treatment.
Journal ArticleDOI
FADD as a key molecular player in cancer progression
TL;DR: Fas-associated protein with death domain (FADD) was initially identified as an adaptor protein for death receptor-mediated extrinsic apoptosis and plays a vital role in non-apoptotic cellular processes, such as proliferation, autophagy and necroptosis as discussed by the authors .
Journal ArticleDOI
A Ferroptosis Molecular Subtype-Related Signature for Predicting Prognosis and Response to Chemotherapy in Patients with Chronic Lymphocytic Leukemia
H Y Gong,Heng Li,Qin Yang,Guangxiong Zhang,Hong Liu,Zekang Ma,Hong-mei Peng,Lin Nie,Xiaojuan Xiao,Jing Lu +9 more
TL;DR: This study investigated the stratification and prognostic role of ferroptosis-related genes in CLL patients of ICGC cohort, developed an eight-gene signature, and explored the potential effect of chemotherapy between the two risk groups.
References
More filters
Journal ArticleDOI
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung,Jacques Ferlay,Rebecca L. Siegel,Mathieu Laversanne,Isabelle Soerjomataram,Ahmedin Jemal,Freddie Bray +6 more
TL;DR: The GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer (IARC) as mentioned in this paper show that female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung cancer, colorectal (11 4.4%), liver (8.3%), stomach (7.7%) and female breast (6.9%), and cervical cancer (5.6%) cancers.
Journal ArticleDOI
The 2007 WHO Classification of Tumours of the Central Nervous System
David N. Louis,Hiroko Ohgaki,Otmar D. Wiestler,Webster K. Cavenee,Peter C. Burger,Anne Jouvet,Bernd W. Scheithauer,Paul Kleihues +7 more
TL;DR: The fourth edition of the World Health Organization (WHO) classification of tumours of the central nervous system, published in 2007, lists several new entities, including angiocentric glioma, papillary glioneuronal tumour, rosette-forming glioneurs tumour of the fourth ventricle, Papillary tumourof the pineal region, pituicytoma and spindle cell oncocytoma of the adenohypophysis.
Journal ArticleDOI
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon,Kathryn M. Lemberg,Michael R. Lamprecht,Rachid Skouta,Eleina M. Zaitsev,Caroline E Gleason,Darpan N Patel,Andras J. Bauer,Alexandra M. Cantley,Wan Seok Yang,Barclay Morrison,Brent R. Stockwell,Brent R. Stockwell +12 more
TL;DR: This paper identified the small molecule ferrostatin-1 as a potent inhibitor of ferroptosis in cancer cells and glutamate-induced cell death in organotypic rat brain slices, suggesting similarities between these two processes.
Journal ArticleDOI
Regulation of Ferroptotic Cancer Cell Death by GPX4
Wan Seok Yang,Rohitha SriRamaratnam,Matthew Welsch,Kenichi Shimada,Rachid Skouta,Vasanthi S. Viswanathan,Vasanthi S. Viswanathan,Jaime H. Cheah,Paul A. Clemons,Alykhan F. Shamji,Clary B. Clish,Lewis M. Brown,Albert W. Girotti,Virginia W. Cornish,Stuart L. Schreiber,Brent R. Stockwell +15 more
TL;DR: Targeted metabolomic profiling and chemoproteomics revealed that GPX4 is an essential regulator of ferroptotic cancer cell death and sensitivity profiling in 177 cancer cell lines revealed that diffuse large B cell lymphomas and renal cell carcinomas are particularly susceptible to GPx4-regulated ferroPTosis.
Journal ArticleDOI
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Brent R. Stockwell,José Pedro Friedmann Angeli,Hülya Bayır,Ashley I. Bush,Marcus Conrad,Scott J. Dixon,Simone Fulda,Susan Gascon,Stavroula K. Hatzios,Valerian E. Kagan,Kay Noel,Xuejun Jiang,Andreas Linkermann,Maureen E. Murphy,Michael Overholtzer,Atsushi Oyagi,Gabriela Carolina Pagnussat,Jason Park,Qitao Ran,Craig S. Rosenfeld,Konstantin Salnikow,Daolin Tang,Daolin Tang,Frank M. Torti,Suzy V. Torti,Shinya Toyokuni,K. A. Woerpel,Donna D. Zhang +27 more
TL;DR: The mechanisms underlying ferroptosis are reviewed, connections to other areas of biology and medicine are highlighted, and tools and guidelines for studying this emerging form of regulated cell death are recommended.