Rong Wu

TL;DR: It is discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear receptor TR3, and implicates a new approach to melanoma therapy through activation of a mitochondrial signaling pathway that integrates a nuclear receptor with autophagy for cell death.

TL;DR: It is demonstrated that the orphan nuclear receptor Nur77 binds and sequesters LKB1 in the nucleus, thereby attenuating AMPK activation and implicates Nur77 as a new and amenable target for the design and development of therapeutics to treat metabolic diseases.

TL;DR: It is discovered that nuclear receptor Nur77 expression is lower in the hypothalamus of obese mice compared with normal mice, opening a new avenue for regulating metabolism with Nur77 as the positive modulator in the leptin-driven antiobesity in the amygdala.

TL;DR: It is demonstrated that the orphan nuclear receptor TR3 suppresses DSB repair by blocking Ku80 DNA-end binding activity and promoting DNA-PK-induced p53 activity in hepatoma cells, and novel functions for TR3 are revealed, suggesting that TR3 is a potential target for cancer radiotherapy.

TL;DR: It is demonstrated that cisplatin effectively induces orphan nuclear receptor TR3 phosphorylation by activating Chk2 kinase activity and promoting cross talk between these two proteins, thereby contributing to the repression of intestinal tumorigenesis via apoptosis.