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Lianru Zhang
Researcher at Xiamen University
Publications - 17
Citations - 768
Lianru Zhang is an academic researcher from Xiamen University. The author has contributed to research in topics: Kinase & Apoptosis. The author has an hindex of 11, co-authored 14 publications receiving 648 citations.
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Journal ArticleDOI
Cytosporone B is an agonist for nuclear orphan receptor Nur77
Yan-yan Zhan,Xiping Du,Hang-zi Chen,Jingjing Liu,Bi-xing Zhao,Danhong Huang,Guideng Li,Qingyan Xu,Ming-Qing Zhang,Bart C. Weimer,Dong Chen,Zhe Cheng,Lianru Zhang,Qinxi Li,Shaowei Li,Zhonghui Zheng,Siyang Song,Yaojian Huang,Zhiyun Ye,Wenjin Su,Sheng-Cai Lin,Yuemao Shen,Qiao Wu +22 more
TL;DR: The octaketide cytosporone B (Csn-B) is a naturally occurring agonist for Nur77 that induced apoptosis and retarded xenograft tumor growth by inducing Nur77 expression, translocating Nur77 to mitochondria to cause cytochrome c release and may be useful as a reagent to increase understanding of Nur77 biological function.
Journal ArticleDOI
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Yan-yan Zhan,Yan Chen,Qian Zhang,Jia-Jia Zhuang,Min Tian,Hang-zi Chen,Lianru Zhang,Hong-Kui Zhang,Jian-ping He,Wei-jia Wang,Rong Wu,Yuan Wang,Chunfang Shi,Kai Yang,An-zhong Li,Yong-zhen Xin,Terytty Yang Li,James Y. Yang,Zhonghui Zheng,Chun-dong Yu,Sheng-Cai Lin,Chawnshang Chang,Pei-Qiang Huang,Tianwei Lin,Qiao Wu +24 more
TL;DR: It is demonstrated that the orphan nuclear receptor Nur77 binds and sequesters LKB1 in the nucleus, thereby attenuating AMPK activation and implicates Nur77 as a new and amenable target for the design and development of therapeutics to treat metabolic diseases.
Journal ArticleDOI
A Unique Pharmacophore for Activation of the Nuclear Orphan Receptor Nur77 In vivo and In vitro
Jingjing Liu,Huini Zeng,Lianru Zhang,Yan-yan Zhan,Yan Chen,Yuan Wang,Juan Wang,Shao-hua Xiang,Wen-Jun Liu,Wei-jia Wang,Hang-zi Chen,Yuemao Shen,Wenjin Su,Pei-Qiang Huang,Hong-Kui Zhang,Qiao Wu +15 more
TL;DR: A pathway for rational design of Csn-B-derived Nur77 agonists as a new class of potent and effective antitumor agents is described.
Journal ArticleDOI
FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation
TL;DR: FW-04-806 displays promising antitumor activity against breast cancer cells both in vitro and in vivo, especially for HER2-overexpressed breast cancers cells.
Journal ArticleDOI
Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells.
TL;DR: This study is the first to show that GB inhibits heat shock protein 90 (Hsp90) and down-regulates TNF-α/NF-κB in HeLa cells and may be useful as a probe to increase understanding of the biological functions of Hsp90.