Yan Chen

TL;DR: These findings uncover an activating pathway that integrates protein phosphorylation and acetylation to connect growth factor deprivation to autophagy when deprived of serum but not glucose.

TL;DR: It is discovered that melanoma, which is generally resistant to drug-induced apoptosis, can undergo autophagic cell death with the participation of orphan nuclear receptor TR3, and implicates a new approach to melanoma therapy through activation of a mitochondrial signaling pathway that integrates a nuclear receptor with autophagy for cell death.

TL;DR: It is demonstrated that the orphan nuclear receptor Nur77 binds and sequesters LKB1 in the nucleus, thereby attenuating AMPK activation and implicates Nur77 as a new and amenable target for the design and development of therapeutics to treat metabolic diseases.

TL;DR: It is shown that orphan nuclear receptor Nur77 (also known as TR3) can enhance resistance to lipopolysaccharide-induced sepsis in mice by inhibiting NF-κB activity and suppressing aberrant cytokine production.

TL;DR: A pathway for rational design of Csn-B-derived Nur77 agonists as a new class of potent and effective antitumor agents is described.