R
Rongxin Chen
Researcher at Fudan University
Publications - 79
Citations - 1749
Rongxin Chen is an academic researcher from Fudan University. The author has contributed to research in topics: Hepatocellular carcinoma & Medicine. The author has an hindex of 23, co-authored 66 publications receiving 1224 citations. Previous affiliations of Rongxin Chen include Chinese Ministry of Education.
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Journal ArticleDOI
Vascular endothelial cells facilitated HCC invasion and metastasis through the Akt and NF-κB pathways induced by paracrine cytokines
Yaohui Wang,Yinying Dong,Wei-Min Wang,Xiaoying Xie,Zhiming Wang,Rongxin Chen,Jie Chen,Dong-Mei Gao,Jiefeng Cui,Zhenggang Ren +9 more
TL;DR: Subcutaneous tumorigenicity of MHCC97H cells in nude mice was promoted by HUVECs and its invasion/metastasis associated genes were significantly upregulated, unveiling a new paradigm in which endothelial cells function as initiators of molecular crosstalks that enhance survival, migration and invasion of HCC cells.
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Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis.
Yinying Dong,Qiongdan Zheng,Zhiming Wang,Xia-Hui Lin,Yang You,Sifan Wu,Yaohui Wang,Chao Hu,Xiaoying Xie,Jie Chen,Dong-Mei Gao,Yan Zhao,Wei-Zhong Wu,Yinkun Liu,Zhenggang Ren,Rongxin Chen,Jiefeng Cui +16 more
TL;DR: Higher matrix stiffness as an initiator triggers epithelial-mesenchymal transition (EMT) in HCC cells independently, and three signaling pathways converging on Snail expression contribute to this pathological process.
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Matrix stiffness-upregulated LOXL2 promotes fibronectin production, MMP9 and CXCL12 expression and BMDCs recruitment to assist pre-metastatic niche formation.
Sifan Wu,Qiongdan Zheng,Xiaoxia Xing,Yinying Dong,Yaohui Wang,Yang You,Rongxin Chen,Chao Hu,Jie Chen,Dong-Mei Gao,Yan Zhao,Zhiming Wang,Tong-Chun Xue,Zhenggang Ren,Jiefeng Cui +14 more
TL;DR: Results indicated that the secreted LOXL2 facilitated the motility of HCC cells and strengthened CTCs settlement on the remodeled matrix “soil”.
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M2-polarized tumor-associated macrophages facilitated migration and epithelial-mesenchymal transition of HCC cells via the TLR4/STAT3 signaling pathway
Rong-Rong Yao,Rong-Rong Yao,Jing-Huan Li,Jing-Huan Li,Rui Zhang,Rui Zhang,Rongxin Chen,Rongxin Chen,Yan-Hong Wang,Yan-Hong Wang +9 more
TL;DR: M2-polarized macrophages facilitated the migration and EMT of HCC cells via the TLR4/STAT3 signaling pathway, suggesting thatTLR4 may be a novel therapeutic target.
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The Significance of MMP-9 Over MMP-2 in HCC Invasiveness and Recurrence of Hepatocellular Carcinoma After Curative Resection
Rongxin Chen,Jiefeng Cui,Changde Xu,Tong-Chun Xue,Kun Guo,Dong-Mei Gao,Yinkun Liu,Sheng-Long Ye,Zhenggang Ren +8 more
TL;DR: MMP-9 is superior to MMP-2 for the prediction of tumor recurrence and survival in HCC patients after surgical resection and the prognostic value of M MP-9 overexpression was validated in the independent data set.