R
Rooban B. Nahomi
Researcher at Case Western Reserve University
Publications - 20
Citations - 382
Rooban B. Nahomi is an academic researcher from Case Western Reserve University. The author has contributed to research in topics: Crystallin & Acetylation. The author has an hindex of 9, co-authored 17 publications receiving 289 citations. Previous affiliations of Rooban B. Nahomi include University of Colorado Denver & University of Colorado Boulder.
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Journal ArticleDOI
Chaperone peptides of α-crystallin inhibit epithelial cell apoptosis, protein insolubilization, and opacification in experimental cataracts.
Rooban B. Nahomi,Benlian Wang,Cibin T. Raghavan,Oliver H. Voss,Andrea I. Doseff,Puttur Santhoshkumar,Ram H. Nagaraj +6 more
TL;DR: The results suggest that the α-crystallin chaperone peptides could be used as therapeutic agents to treat cataracts and diseases in which protein aggregation and apoptosis are contributing factors.
Journal ArticleDOI
Acetylation of αA-crystallin in the human lens: effects on structure and chaperone function.
Ram H. Nagaraj,Rooban B. Nahomi,Shilpa Shanthakumar,Mikhail Linetsky,Smitha Padmanabha,Nagarekha Pasupuleti,Benlian Wang,Puttur Santhoshkumar,Alok Kumar Panda,Ashis Biswas +9 more
TL;DR: The data suggest that acetylation of αA-crystallin occurs in the human lens and that it affects the chaperone function of the protein.
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Pro-inflammatory cytokines downregulate Hsp27 and cause apoptosis of human retinal capillary endothelial cells.
TL;DR: It is suggested that pro-inflammatory cytokines induce the formation of ROS and NO, which, through theformation of peroxynitrite, reduce the Hsp27 content and bring about apoptosis of retinal capillary endothelial cells.
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Identification of peptides in human Hsp20 and Hsp27 that possess molecular chaperone and anti-apoptotic activities
TL;DR: This study found that scrambling the last four amino acids in the two peptides made them unable to enter cells and ineffective against stress-induced apoptosis, and prevented sodium-selenite-induced cataract formation in rats by inhibiting protein aggregation and oxidative stress.
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The Combined Effect of Acetylation and Glycation on the Chaperone and Anti-apoptotic Functions of Human α-Crystallin
TL;DR: Lysine acetylation improves anti-apoptotic function of α-crystallin and prevents ascorbate-mediated loss of chaperone function, and data demonstrate that lysineacetylation and AGE formation can occur concurrently in α- Crystallin of human lens.