R
Roopali Roy
Researcher at Boston Children's Hospital
Publications - 46
Citations - 2755
Roopali Roy is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 22, co-authored 42 publications receiving 2545 citations. Previous affiliations of Roopali Roy include Harvard University & Brigham and Women's Hospital.
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Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer.
TL;DR: The matrix metalloproteinase (MMP) family of enzymes is comprised of critically important extracellular matrix remodeling proteases whose activity has been implicated in a number of key normal and pathologic processes.
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ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage
TL;DR: Data demonstrate for the first time that ADAM 12 is a gelatinase, that it can be detected in breast cancer patient urine, and that increased urinary levels of this protein correlate with breast cancer progression.
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Microdeformational wound therapy: effects on angiogenesis and matrix metalloproteinases in chronic wounds of 3 debilitated patients.
Arin K. Greene,Mark Puder,Roopali Roy,Danielle A. Arsenault,Stephanie Kwei,Marsha A. Moses,Dennis P. Orgill +6 more
TL;DR: Wounds subjected to MDWT had greater microvessel density compared with the same wound prior to treatment, and MMP-9/NGAL (neutrophil gelatinase-associated lipocalin) and active M MP-2 were reduced by 15%–76% in MDWT-treated wounds.
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Making the cut: protease-mediated regulation of angiogenesis.
TL;DR: The contribution of proteases including matrix metalloproteases, and the closely related ADAM and ADAMTS families, as well as cysteine and serine proteases, in the positive and negative regulation of angiogenesis as mediated by degradation of the endothelial basement membrane and extracellular matrix proteins.
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Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus.
Michael W. W. Adams,James F. Holden,Angeli Lal Menon,Gerrit J. Schut,Amy M. Grunden,Chun Hou,Andrea M. Hutchins,Francis E. Jenney,Chulhwan Kim,Kesen Ma,Guangliang Pan,Roopali Roy,Rajat Sapra,Sherry V. Story,Marc F. J. M. Verhagen +14 more
TL;DR: This study provides the first evidence for a highly regulated fermentation-based metabolism in P. furiosus and a significant regulatory role for elemental sulfur or its metabolites.