R
Rory B. Conolly
Researcher at United States Environmental Protection Agency
Publications - 151
Citations - 6330
Rory B. Conolly is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Physiologically based pharmacokinetic modelling & Population. The author has an hindex of 44, co-authored 147 publications receiving 5961 citations. Previous affiliations of Rory B. Conolly include University of Michigan & COMSATS Institute of Information Technology.
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Journal ArticleDOI
Endocrine Disrupting Chemicals in Fish: Developing Exposure Indicators and Predictive Models of Effects Based on Mechanism of Action
Gerald T. Ankley,David C. Bencic,Michael Breen,Timothy W. Collette,Rory B. Conolly,Nancy D. Denslow,Stephen W. Edwards,Drew R. Ekman,Natàlia Garcia-Reyero,Kathleen M. Jensen,James M. Lazorchak,Dalma Martinović,David H. Miller,Edward J. Perkins,Edward F. Orlando,Daniel L. Villeneuve,Rong-Lin Wang,Karen H. Watanabe +17 more
TL;DR: An overview and illustrative results from a large, integrated project that assesses the effects of EDCs on two small fish models, the fathead minnow (Pimephales promelas) and zebrafish, are provided.
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Nonmonotonic Dose-Response Relationships: Mechanistic Basis, Kinetic Modeling, and Implications for Risk Assessment
Rory B. Conolly,Werner K. Lutz +1 more
TL;DR: This analysis should promote a scientific discussion of biphasic dose responses and the concept termed "hormesis," and of default procedures for low-dose extrapolation in toxicological risk assessment.
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Modeling Interindividual Variation in Physiological Factors Used in PBPK Models of Humans
Paul S. Price,Rory B. Conolly,Christine F. Chaisson,Elizabeth A. Gross,John S. Young,Eric T. Mathis,Douglas R. Tedder +6 more
TL;DR: This project develops a source of data for human physiological parameters where (1) the parameter values for an individual are correlated with one another, and (2) values of parameters capture interindividual variation in populations of a specific gender, race, and age range.
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Arsenic-Induced Carcinogenesis—Oxidative Stress as a Possible Mode of Action and Future Research Needs for More Biologically Based Risk Assessment
Kirk T. Kitchin,Rory B. Conolly +1 more
TL;DR: An efficient approach to the development of a BBDR model for iAs that would reduce uncertainties in its cancer risk assessment is outlined, illustrated by using oxidative stress as the carcinogenic MOA for i as but would be generically applicable to other MOAs.
Journal ArticleDOI
Development of a physiologically based pharmacokinetic model for chloroform.
Richard A. Corley,Alan L. Mendrala,F.A. Smith,D.A. Staats,Michael L. Gargas,Rory B. Conolly,Melvin E. Andersen,Richard H. Reitz +7 more
TL;DR: The metabolic activation of chloroform to toxic intermediates was shown to occur most rapidly in the mouse, less rapid in the rat, and most slowly in humans, consistent with previous reports.