D
Drew R. Ekman
Researcher at United States Environmental Protection Agency
Publications - 43
Citations - 2397
Drew R. Ekman is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Metabolite & Xenobiotic. The author has an hindex of 26, co-authored 41 publications receiving 2077 citations. Previous affiliations of Drew R. Ekman include National Institute of Standards and Technology & University of Georgia.
Papers
More filters
Journal ArticleDOI
Endocrine Disrupting Chemicals in Fish: Developing Exposure Indicators and Predictive Models of Effects Based on Mechanism of Action
Gerald T. Ankley,David C. Bencic,Michael Breen,Timothy W. Collette,Rory B. Conolly,Nancy D. Denslow,Stephen W. Edwards,Drew R. Ekman,Natàlia Garcia-Reyero,Kathleen M. Jensen,James M. Lazorchak,Dalma Martinović,David H. Miller,Edward J. Perkins,Edward F. Orlando,Daniel L. Villeneuve,Rong-Lin Wang,Karen H. Watanabe +17 more
TL;DR: An overview and illustrative results from a large, integrated project that assesses the effects of EDCs on two small fish models, the fathead minnow (Pimephales promelas) and zebrafish, are provided.
Journal ArticleDOI
A direct cell quenching method for cell-culture based metabolomics
TL;DR: A novel sample preparation method for metabolomics applications using adherent mammalian cells, which eliminates the time consumption and physiological stress of the trypsinization and wash/centrifuge steps and exhibits greater metabolite retention.
Journal ArticleDOI
Metabolomics in Toxicology and Preclinical Research
Tzutzuy Ramirez,Mardas Daneshian,Hennicke Kamp,Frédéric Y. Bois,Malcolm R. Clench,Muireann Coen,Beth Donley,Steven M. Fischer,Drew R. Ekman,Eric Fabian,Claude Guillou,Joachim Heuer,Helena T. Hogberg,Harald Jungnickel,Hector C. Keun,G. Krennrich,Eckart Krupp,Andreas Luch,Fozia Noor,Erik Peter,Bjoern Riefke,Mark Seymour,Nigel Skinner,Lena Smirnova,Elwin Verheij,Silvia Wagner,Thomas Hartung,Bennard van Ravenzwaay,Marcel Leist +28 more
TL;DR: Three working groups addressing questions regarding 1) metabolomics for in vitro studies 2) the appropriate use of metabolomics in systems toxicology, and 3) use of metabolites in a regulatory context are addressed.
Journal ArticleDOI
Spectral relative standard deviation : a practical benchmark in metabolomics
TL;DR: Spectrum-wide relative standard deviations are calculated for ten metabolomics datasets, spanning a variety of sample types from mammals, fish, invertebrates and a cell line, and displayed succinctly as boxplots to propose spectral RSDs and their median values contained herein as practical benchmarks for metabolomics studies.
Journal ArticleDOI
A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Stefan Scholz,Erika Sela,Ludek Blaha,Thomas Braunbeck,Malyka Galay-Burgos,Mauricio García-Franco,Joaquin Guinea,Nils Klüver,Kristin Schirmer,Kristin Schirmer,Katrin Tanneberger,Marysia Tobor-Kapłon,Hilda Witters,Scott E. Belanger,Emilio Benfenati,Stuart Creton,Mark T. D. Cronin,Rik I.L. Eggen,Rik I.L. Eggen,Michelle R. Embry,Drew R. Ekman,Anne Gourmelon,Marlies Halder,Barry Hardy,Thomas Hartung,Bruno Hubesch,Dirk Jungmann,Mark A. Lampi,Lucy E. J. Lee,Marc Léonard,Eberhard Küster,Adam Lillicrap,Till Luckenbach,Albertinka J. Murk,José María Navas,Willie J.G.M. Peijnenburg,Guillermo Repetto,Edward Salinas,Gerrit Schüürmann,Horst Spielmann,Knut Erik Tollefsen,Susanne Walter-Rohde,Graham Whale,James R. Wheeler,Matthew J. Winter +44 more
TL;DR: An overview on current regulations of chemicals and the requirements for animal tests in environmental hazard and risk assessment is provided and the potential areas for alternative approaches to animal tests using vertebrates in environmental toxicology are highlighted.