R
Rosalind C. Lee
Researcher at University of Massachusetts Medical School
Publications - 17
Citations - 18315
Rosalind C. Lee is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Caenorhabditis elegans & RNA. The author has an hindex of 14, co-authored 17 publications receiving 17115 citations. Previous affiliations of Rosalind C. Lee include Harvard University & Dartmouth College.
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
TL;DR: Two small lin-4 transcripts of approximately 22 and 61 nt were identified in C. elegans and found to contain sequences complementary to a repeated sequence element in the 3' untranslated region (UTR) of lin-14 mRNA, suggesting that lin- 4 regulates lin- 14 translation via an antisense RNA-RNA interaction.
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An Extensive Class of Small RNAs in Caenorhabditis elegans
Rosalind C. Lee,Victor R. Ambros +1 more
TL;DR: Using bioinformatics and cDNA cloning, this work found 15 new miRNA genes in C. elegans that express small transcripts that vary in abundance during larval development, and three of them have apparent homologs in mammals and/or insects.
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The Cold Shock Domain Protein LIN-28 Controls Developmental Timing in C. elegans and Is Regulated by the lin-4 RNA
TL;DR: In this article, Lin-28 encodes a cytoplasmic protein with a cold shock domain and retroviral-type (CCHC) zinc finger motifs, consistent with a role for LIN-28 in posttranscriptional regulation.
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MicroRNAs and other tiny endogenous RNAs in C. elegans
TL;DR: The presence of diverse endogenous siRNAs in normal worms suggests ongoing, genome-wide gene silencing by RNAi, and suggests that diverse modes of small RNA-mediated gene regulation are deployed innormal worms.
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Potent effect of target structure on microRNA function.
TL;DR: A potent effect of target structure on target recognition by miRNAs is indicated and a structure-based framework for genome-wide identification of animal miRNA targets is established.