R
Rosana Hudej
Researcher at University of Ljubljana
Publications - 6
Citations - 131
Rosana Hudej is an academic researcher from University of Ljubljana. The author has contributed to research in topics: Electroporation & In vivo. The author has an hindex of 4, co-authored 6 publications receiving 115 citations. Previous affiliations of Rosana Hudej include BIA Separations (Slovenia).
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Journal ArticleDOI
Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex
Rosana Hudej,Jakob Kljun,Wolfgang Kandioller,Urska Repnik,Boris Turk,Boris Turk,Christian G. Hartinger,Christian G. Hartinger,Bernhard K. Keppler,Damijan Miklavčič,Iztok Turel +10 more
TL;DR: In this article, the crystal structures of the nalidixic acid and its organoruthenium complex were determined, and the aqueous stability of the complex was studied.
Journal ArticleDOI
Cell size dynamics and viability of cells exposed to hypotonic treatment and electroporation for electrofusion optimization
TL;DR: The hypotonic treatment in itself did not significantly affect the cell viability; however, electric field parameters for electroporation should be carefully selected taking into account the hypotonically induced volume increase of cells.
Journal Article
The influence of electroporation on cytotoxicity of anticancer ruthenium(III) complex KP1339 in vitro and in vivo.
Rosana Hudej,Iztok Turel,Maša Kandušer,Janez Ščančar,Simona Kranjc,Gregor Sersa,Damijan Miklavčič,Michael A. Jakupec,Bernhard K. Keppler,Maja Cemazar +9 more
TL;DR: The results show that electroporation does not potentiate the cytotoxicity of KP1339 in vitro, but significantly potentiates antitumour effectiveness in vivo, causing persistently higher intratumoural ruthenium content throughout the whole observation period.
Journal ArticleDOI
Modulation of Activity of Known Cytotoxic Ruthenium(III) Compound (KP418) with Hampered Transmembrane Transport in Electrochemotherapy In Vitro and In Vivo
Rosana Hudej,Rosana Hudej,Damijan Miklavčič,Maja Cemazar,Vesna Todorovic,Gregor Sersa,Alberta Bergamo,Gianni Sava,Anze Martincic,Janez Ščančar,Bernhard K. Keppler,Iztok Turel +11 more
TL;DR: Electroporation leads to increased cellular accumulation and cytotoxicity of KP418 in murine melanoma cell lines with low and high metastatic potential, but not in murines fibrosarcoma cell line SA-1 in vitro which is probably due to variable effectiveness of ECT in different cell lines and tumors.
Journal ArticleDOI
Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study
Spela Kos,Masa Bosnjak,Tanja Jesenko,Bostjan Markelc,Urska Kamensek,Katarina Znidar,Urska Matkovic,Andrej Rencelj,Gregor Sersa,Rosana Hudej,Aneja Tuljak,Matjaz Peterka,Maja Cemazar +12 more
TL;DR: In this article, the authors constructed and developed the production process for the clinical grade quality antibiotic resistance gene-free plasmid encoding human IL-12 (p21-hIL-12-ORT) and its ortholog encoding murine IL-13 (p 21-mIL-13-ORT).