R
Rosana L. Pagano
Researcher at University of São Paulo
Publications - 45
Citations - 1374
Rosana L. Pagano is an academic researcher from University of São Paulo. The author has contributed to research in topics: Nociception & Neuropathic pain. The author has an hindex of 18, co-authored 37 publications receiving 1091 citations. Previous affiliations of Rosana L. Pagano include Instituto Butantan & AmeriCorps VISTA.
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Journal ArticleDOI
Hemopressin is an inverse agonist of CB1 cannabinoid receptors.
Andrea S. Heimann,Ivone Gomes,Camila Squarzoni Dale,Rosana L. Pagano,Achla Gupta,Laura L. de Souza,Augusto Ducati Luchessi,Leandro M. Castro,Renata Giorgi,Vanessa Rioli,Emer S. Ferro,Lakshmi A. Devi +11 more
TL;DR: The identification of hemopressin (PVNFKFLSH) as a peptide ligand that selectively binds CB1 cannabinoid receptors is identified and it is found that it exhibits antinociceptive effects when administered by either intrathecal, intraplantar, or oral routes, underscoring hemopressingin's therapeutic potential.
Journal ArticleDOI
Motor cortex stimulation inhibits thalamic sensory neurons and enhances activity of PAG neurons: Possible pathways for antinociception
Rosana L. Pagano,Erich Talamoni Fonoff,Camila Squarzoni Dale,Gerson Ballester,Manoel Jacobsen Teixeira,Luiz R.G. Britto +5 more
TL;DR: The present findings suggest that inhibition of thalamic sensory neurons and disinhibition of the neurons in periaqueductal gray are at least in part responsible for the motor cortex stimulation‐induced antinociception.
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Transdural motor cortex stimulation reverses neuropathic pain in rats: a profile of neuronal activation.
Rosana L. Pagano,Danielle V. Assis,Joseph A. Clara,Joseph A. Clara,Adilson S. Alves,Camila Squarzoni Dale,Manoel Jacobsen Teixeira,Erich Talamoni Fonoff,Luiz R.G. Britto +8 more
TL;DR: The present findings suggest that MCS reverts neuropathic pain phenomena in rats, mimicking the effect observed in humans, through activation of the limbic and descending pain inhibitory systems.
Journal ArticleDOI
Antinociception induced by epidural motor cortex stimulation in naive conscious rats is mediated by the opioid system
Erich Talamoni Fonoff,Camila Squarzoni Dale,Rosana L. Pagano,Carina Cicconi Paccola,Gerson Ballester,Manoel Jacobsen Teixeira,Renata Giorgi +6 more
TL;DR: Data shown herein demonstrate that epidural electrical MCS elicits a substantial and selective antinociceptive effect, which is mediated by opioids, and abolished the increase in nociception threshold induced by MCS.
Journal ArticleDOI
Functional mapping of the motor cortex of the rat using transdural electrical stimulation
Erich Talamoni Fonoff,Erich Talamoni Fonoff,José F. Pereira,Leonardo Valente Camargo,Camila Squarzoni Dale,Rosana L. Pagano,Rosana L. Pagano,Gerson Ballester,Manoel Jacobsen Teixeira +8 more
TL;DR: This method allows a non-invasive mapping of the surface of the neocortex providing a differentiation of representative motor areas in rat motor cortex, possibly benefiting patients who do not respond to this neuromodulation therapy.