Rosario Samanin

TL;DR: The results suggest that the ability of serotonin uptake inhibitors to enhance the extracellular concentrations of serotonin in the dorsal raphe attenuates the drug's effect in the frontal cortex.

TL;DR: For the remainder of the population whose hyperlipidaemia is polygenically determined, the liability to coronary heart disease might be substantially reduced by simple and appropriate environmental measures aimed at reducing the total liability.

TL;DR: The results suggest that dopaminergic D1 (but not D2) and glutamatergic NMDA and NMDA receptors are involved in the primary rewarding properties of cocaine (as assessed by the establishment of CPP) whereas the AMPA/kainate receptors are important only for the behaviour elicited by the stimuli previously associated with the drug action (CPP expression).

TL;DR: Changes in P-gp mRNA levels occur in limbic areas after both acute and chronic epileptic activity, suggesting that seizure-induced mdr mRNA expression contributes to MDR in epilepsy.

TL;DR: The data suggest that the decrease of food intake induced by metachlorophenylpiperazine depends on its ability to act as a serotonin agonist in the brain, which could prove an important tool for studies aimed at elucidating the functional role of serotonin in the central nervous system.