T
Tiziana Mennini
Researcher at Mario Negri Institute for Pharmacological Research
Publications - 271
Citations - 10924
Tiziana Mennini is an academic researcher from Mario Negri Institute for Pharmacological Research. The author has contributed to research in topics: Receptor & Serotonin. The author has an hindex of 53, co-authored 271 publications receiving 10631 citations. Previous affiliations of Tiziana Mennini include University of Calabria & University of Naples Federico II.
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Journal ArticleDOI
Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress
Anna-Leena Sirén,Maddalena Fratelli,Michael Brines,Christoph G. Goemans,Simona Casagrande,Piotr Lewczuk,Sonja Keenan,Christoph H. Gleiter,Claudio Pasquali,Annalisa Capobianco,Tiziana Mennini,Rolf Heumann,Anthony Cerami,Hannelore Ehrenreich,Pietro Ghezzi +14 more
TL;DR: Data suggest that inhibition of neuronal apoptosis underlies short latency protective effects of EPO after cerebral ischemia and other brain injuries, and the neurotrophic actions suggest there may be longer-latency effects as well.
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Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis.
Pia Villa,Paolo Bigini,Tiziana Mennini,Davide Agnello,Teresa Laragione,Alfredo Cagnotto,Barbara Viviani,Marina Marinovich,Anthony Cerami,Thomas Coleman,Michael Brines,Pietro Ghezzi,Pietro Ghezzi +12 more
TL;DR: It is shown that recombinant human EPO markedly reduces astrocyte activation and the recruitment of leukocytes and microglia into an infarction produced by middle cerebral artery occlusion in rats, suggesting that rhEPO attenuates ischemia-induced inflammation by reducing neuronal death rather than by direct effects upon EPO-R–expressing inflammatory cells.
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Erythropoietin exerts an anti-inflammatory effect on the CNS in a model of experimental autoimmune encephalomyelitis
Davide Agnello,Paolo Bigini,Pia Villa,Tiziana Mennini,Anthony Cerami,Michael Brines,Pietro Ghezzi +6 more
TL;DR: EPO delayed the increase of TNF levels, without altering their peak levels, and markedly reduced those of IL-6 and this data suggest that EPO might act as a protective cytokine in inflammatory pathologies of the CNS.
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Nonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin
Michael Brines,Nimesh S. A. Patel,Pia Villa,Courtenay Brines,Tiziana Mennini,Massimiliano De Paola,Zübeyde Erbayraktar,Serhat Erbayraktar,Bruno Sepodes,Christoph Thiemermann,Pietro Ghezzi,Pietro Ghezzi,Michael A. Yamin,Carla Hand,Qiao wen Xie,Thomas Coleman,Thomas Coleman,Anthony Cerami +17 more
TL;DR: It is demonstrated that helix B of EPO, which faces the aqueous medium when EPO is bound to the receptor homodimer, is both neuroprotective in vitro and tissue protective in vivo in a variety of models, including ischemic stroke, diabetes-induced retinal edema, and peripheral nerve trauma.
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Riluzole enhances the activity of glutamate transporters GLAST, GLT1 and EAAC1.
TL;DR: In this paper, riluzole significantly increased glutamate uptake in a dose-dependent manner; kinetic analysis indicated that the apparent affinity of glutamate for the transporters was significantly increased, with similar effects in the three cell lines.