Rose-Laure Indorato

TL;DR: It is concluded that continuous Cdk1 activity is not essential to maintain the mitotic state and that phosphatase activity directed at Cdk 1 substrates is largely quiescent during mitosis.

TL;DR: An initial structure-activity relationship study on a series of STLC analogues reveals the minimal skeleton necessary for Eg5 inhibition as well as indications of how to obtain more potent analogues.

TL;DR: Proteome analysis following STLC treatment revealed 33 differentially regulated proteins of various cellular processes, 31 of which can be linked to apoptotic cell death, Interestingly, four identified proteins, chromobox protein homolog, RNA‐binding Src associated in mitosis 68 kDa protein, stathmin, and translationally controlled tumor protein can belinked to mitotic and apoptotic processes.

TL;DR: It is predicted that resistance can be overcome by inhibitors that bind to other than the Eg5 loop-L5 binding site having different chemical scaffolds, and that allostery-dependent resistance to Eg5 inhibitors may also occur in cells and may have positive implications in chemotherapy since once diagnosed may be beneficial following cessation of the chemotherapeutic regimen.

TL;DR: A structural model is generated that suggests that the interaction of Rev with the C-terminal portion of importin-beta resembles that of Importin-alpha's IBB domain, which agrees with previous reports that the IBBdomain can compete with Rev for importin -beta binding.