R
Roshan M. Kumar
Researcher at Massachusetts Institute of Technology
Publications - 25
Citations - 9792
Roshan M. Kumar is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Cellular differentiation & Regulation of gene expression. The author has an hindex of 14, co-authored 25 publications receiving 9300 citations. Previous affiliations of Roshan M. Kumar include Wyss Institute for Biologically Inspired Engineering & Harvard University.
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Translational genomics in Brassica crops: challenges, progress, and future prospects
TL;DR: The potential of recently adopted genetic and genomic resources, as well as the basic knowledge obtained from studying the closest model plant A. thaliana, to accelerate the crop improvement programs in Brassica crops is summarized.
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Evidence That Gene Activation and Silencing during Stem Cell Differentiation Requires a Transcriptionally Paused Intermediate State
Jonathan L. Golob,Roshan M. Kumar,Matthew G. Guenther,Lil Pabon,Gabriel A. Pratt,Jeanne F. Loring,Louise C. Laurent,Louise C. Laurent,Richard A. Young,Charles E. Murry +9 more
TL;DR: Findings indicate that the paused state may be the major transition state for genes changing expression during differentiation, and implicate control of transcriptional elongation as a key checkpoint in lineage specification.
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Evolution, expression differentiation and interaction specificity of heterotrimeric G-protein subunit gene family in the mesohexaploid Brassica rapa.
TL;DR: Yeast-based interaction analysis showed that G-protein subunits interacted in most of the possible combinations, with some degree of subunit-specific interaction specificity, to control the functional selectivity of G- protein heterotrimer in different cell and tissue-types or in response to different environmental conditions.
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Differential expression and interaction specificity of the heterotrimeric G-protein family in Brassica nigra reveal their developmental- and condition-specific roles.
TL;DR: The authors' data on physical interactions coupled with the co-expression pattern of the multiple G-protein subunit genes suggested that tissue- and condition-specific functional combinations of Gαβγ heterotrimers may exist in paleopolyploid B. nigra, to control diverse growth and development processes.
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A modular, bifunctional RNA that integrates itself into a target RNA.
Roshan M. Kumar,Gerald F. Joyce +1 more
TL;DR: In vitro evolution was used to optimize the behavior of the conjoined ribozymes, resulting in bifunctional molecules with substantially improved integration activity and shed light on the evolution of modular enzymes and the obstacles that must be overcome in bringing together independent functional domains.