R
Ross W. Stephens
Researcher at Australian National University
Publications - 133
Citations - 5884
Ross W. Stephens is an academic researcher from Australian National University. The author has contributed to research in topics: Plasminogen activator & Urokinase. The author has an hindex of 41, co-authored 133 publications receiving 5768 citations. Previous affiliations of Ross W. Stephens include University of Giessen & Finsen Laboratory.
Papers
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Journal ArticleDOI
Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactants.
Ross W. Stephens,Jari Pöllänen,Hannele Tapiovaara,K C Leung,P S Sim,E M Salonen,E Rønne,Niels Behrendt,K Danø,Antti Vaheri +9 more
TL;DR: A model for cell surface plasminogen activation is proposed in which plAsminogen binding to cells from serum medium is followed by plasmineogen activation by trace amounts of bound active u-PA, to form bound plasmini, which in turn serves to produce more active u -PA from bound pro-u-PA.
Book ChapterDOI
Directed Plasminogen Activation at the Surface of Normal and Malignant Cells
TL;DR: This chapter discusses the concept of directed cell-surface plasminogen activation and it is clear that the u-PA receptor has a dominant role in directing proteolytic activity at the critical sites of contacts between cells and substratum.
Journal ArticleDOI
Plasma Urokinase Receptor Levels in Patients With Colorectal Cancer: Relationship to Prognosis
Ross W. Stephens,Hans Jørgen Nielsen,Ib Jarle Christensen,Ole Thorlacius-Ussing,Steen Sørensen,Keld Danø,Nils Brünner +6 more
TL;DR: The preoperative plasma suPAR level independently predicted survival of patients with colorectal cancer and the utility of plasma su PAR measurements and cut points in identifying high-risk patients among those with early stage disease is needed.
Journal ArticleDOI
Functional overlap between two classes of matrix‐degrading proteases in wound healing
Leif R. Lund,John Rømer,Thomas H. Bugge,Boye Schnack Nielsen,Thomas Frandsen,Jay L. Degen,Ross W. Stephens,Keld Danø +7 more
TL;DR: The results predict that complete arrest of this latter process in therapeutic settings will require the use of inhibitors of both classes of proteases, probably in the dissection of the fibrin‐rich provisional matrix by migrating keratinocytes.
Journal ArticleDOI
Interaction of plasminogen activator inhibitor (PAI-1) with vitronectin.
E M Salonen,Antti Vaheri,Jari Pöllänen,Ross W. Stephens,P Andreasen,M Mayer,K Danø,J Gailit,Erkki Ruoslahti +8 more
TL;DR: The interaction between vitronectin and PAI-1 may serve to confine pericellular u-PA activity to focal contact sites where cells use proteolysis in regional detachment.