R
Roxanne Letcher
Researcher at University of Michigan
Publications - 2
Citations - 2168
Roxanne Letcher is an academic researcher from University of Michigan. The author has contributed to research in topics: Neurofibromin 1 & Locus (genetics). The author has an hindex of 2, co-authored 2 publications receiving 2099 citations. Previous affiliations of Roxanne Letcher include National Institutes of Health.
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Journal ArticleDOI
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients
Margaret R. Wallace,Douglas A. Marchuk,Lone B. Andersen,Roxanne Letcher,Hana Odeh,Ann M. Saulino,Jane W. Fountain,Anne Brereton,Jane M. Nicholson,Anna L. Mitchell,Bernard H. Brownstein,Francis S. Collins +11 more
TL;DR: The use of chromosome jumping and yeast artificial chromosome technology has now led to the identification of a large (approximately 13 kilobases) ubiquitously expressed transcript (denoted NF1LT) from this region that is definitely interrupted by one and most likely by both translocations, suggesting that NF1 LT represents the elusive NF1 gene.
Journal ArticleDOI
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins.
R. Ballester,Douglas A. Marchuk,Douglas A. Marchuk,Mark S. Boguski,Ann M. Saulino,Ann M. Saulino,Roxanne Letcher,Roxanne Letcher,Michael Wigler,Francis S. Collins,Francis S. Collins +10 more
TL;DR: It is indicated that the NF1 gene product can interact with RAS proteins and structural and functional similarities and differences among the GAP, IRA1, IRA2, and NF1 proteins are demonstrated.