R
Roy D. Schmickel
Researcher at University of Michigan
Publications - 33
Citations - 2085
Roy D. Schmickel is an academic researcher from University of Michigan. The author has contributed to research in topics: Ribosomal RNA & Ribosomal DNA. The author has an hindex of 18, co-authored 33 publications receiving 2058 citations.
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Journal ArticleDOI
Molecular evidence for genetic exchanges among ribosomal genes on nonhomologous chromosomes in man and apes
Norman Arnheim,Mark Krystal,Roy D. Schmickel,Golder N. Wilson,Oliver A. Ryder,Elizabeth A. Zimmer +5 more
TL;DR: It is found that human and ape ribosomal genes undergo concerted evolution involving genetic exchanges among nucleolus organizers on nonhomologous chromosomes.
Journal ArticleDOI
Variation among human 28S ribosomal RNA genes.
Iris L. Gonzalez,Jerome L. Gorski,Thomas J. Campen,D. J. Dorney,Jeanne Erickson,James E. Sylvester,Roy D. Schmickel +6 more
TL;DR: The complete 5025-base sequence of the human 28S rRNA gene is reported and the rapid divergence rates of variable regions in the ribosomal gene may permit answers to the question of time of separation of closely related species.
Journal ArticleDOI
Structure and variation of human ribosomal DNA: molecular analysis of cloned fragments
TL;DR: The boundaries between the 18S r DNA, internal transcribed spacer, 28s rDNA, and external nontranscribed spacer were determined by R-loop analysis, further defining the organization of the ribosomal RNA precursor.
Journal ArticleDOI
Holoprosencephaly in infants of diabetic mothers
Mason Barr,James W. Hanson,Kathleen M. Currey,Stuart Sharp,Helga Toriello,Roy D. Schmickel,Golder N. Wilson +6 more
TL;DR: Incidence figures from newborn surveys demonstrate a risk for holoprosencephaly in infants of diabetic mothers comparable to the 1% risk for caudal regression malformation sequence, which emphasizes the need for pregnancy planning and diabetes control.
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Cockayne Syndrome: A Cellular Sensitivity to Ultraviolet Light
TL;DR: In both Cockayne fibroblast cultures, the rate of removal of thymidine dimer from the irradiated cellular DNA was normal and this demonstration of a cellular defect in Cockayne cells suggests that there may be an enzymatic defect in the repair of UV light-induced damage.