Roya Babaei-Jadidi

TL;DR: Comprehensive screening of glycation adducts revealed the relative and quantitative importance of alpha-oxoaldehyde-derived advanced glycation endproducts in physiological modification of proteins-particularly hydroimidazolones, the efficient renal clearance of freeAdducts, and the marked increases in glycationadducts in diabetes and uraemia.

TL;DR: High-dose thiamine and benfotiamine therapy is a potential novel strategy for the prevention of clinical diabetic nephropathy and countered the accumulation of triosephosphates in experimental diabetes and inhibited the development of incipient nephtropathy.

TL;DR: There are profound increases in proteolytic products of glycated and oxidised proteins in diabetic patients, concurrent with much lower increases in protein glycation and oxidation adduct residues.

TL;DR: It is concluded that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role.

TL;DR: Low plasma thiamine concentration is prevalent in patients with type 1 and type 2 diabetes, associated with increasedThiamine clearance, and the conventional assessment of thiamin status was masked by increased thienine transporter content of erythrocytes.