R
Rudi Busse
Researcher at Goethe University Frankfurt
Publications - 303
Citations - 43274
Rudi Busse is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Endothelium & Nitric oxide. The author has an hindex of 110, co-authored 303 publications receiving 42200 citations. Previous affiliations of Rudi Busse include University of Freiburg & Max Planck Society.
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Journal ArticleDOI
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Stefanie Dimmeler,Ingrid Fleming,Beate Fisslthaler,Corinna Hermann,Rudi Busse,Andreas M. Zeiher +5 more
TL;DR: It is demonstrated that the serine/threonine protein kinase Akt/PKB mediates the activation of eNOS, leading to increased NO production, and represents a novel Ca2+-independent regulatory mechanism for activation ofeNOS.
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Crucial role of endothelium in the vasodilator response to increased flow in vivo
TL;DR: Results suggest that endothelial cells act as mediators of flow-dependent dilation in vasomotor response to increases in flow as observed in conduit arteries.
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Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase
Ingrid Fleming,Rudi Busse +1 more
TL;DR: Simultaneous alterations in the phosphorylation of Ser(1177) and Thr(495) in response to a variety of stimuli are regulated by a number of kinases and phosphatases that continuously associate with and dissociate from the eNOS signaling complex.
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Improvement of Postnatal Neovascularization by Human Adipose Tissue-Derived Stem Cells
Alexandra Miranville,Christopher Heeschen,Coralie Sengenès,Cyrile Anne Curat,Rudi Busse,Anne Bouloumié +5 more
TL;DR: The data indicate the presence of a cell population within the SVF of human AT characterized as CD34+/CD31− exhibiting characteristics of endothelial progenitor cells, therefore, human AT might represent a source of stem/progenitor cells useful for cell therapy to improve vasculogenesis in adults.
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Cytochrome P450 2C is an EDHF synthase in coronary arteries
Beate Fisslthaler,Rüdiger Popp,Ladislau Kiss,Michael Potente,David R. Harder,Ingrid Fleming,Rudi Busse +6 more
TL;DR: It is shown that the induction of cytochrome P450 (CYP) 2C8/34 in native porcine coronary artery endothelial cells by β-naphthoflavone enhances the formation of 11,12-epoxyeicosatrienoic acid, as well as EDHF-mediated hyperpolarization and relaxation.