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Stefanie Dimmeler
Researcher at Goethe University Frankfurt
Publications - 618
Citations - 88185
Stefanie Dimmeler is an academic researcher from Goethe University Frankfurt. The author has contributed to research in topics: Endothelial stem cell & Progenitor cell. The author has an hindex of 147, co-authored 574 publications receiving 81658 citations. Previous affiliations of Stefanie Dimmeler include St. Vincent's Institute of Medical Research & German Cancer Research Center.
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Journal ArticleDOI
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
Stefanie Dimmeler,Ingrid Fleming,Beate Fisslthaler,Corinna Hermann,Rudi Busse,Andreas M. Zeiher +5 more
TL;DR: It is demonstrated that the serine/threonine protein kinase Akt/PKB mediates the activation of eNOS, leading to increased NO production, and represents a novel Ca2+-independent regulatory mechanism for activation ofeNOS.
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Endothelial Progenitor Cells: Characterization and Role in Vascular Biology
Carmen Urbich,Stefanie Dimmeler +1 more
TL;DR: This review summarizes the mechanisms regulating endothelial progenitor cell–mediated neovascularization and reendothelialization and describes the characterization of the different progenitors cell populations.
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Number and Migratory Activity of Circulating Endothelial Progenitor Cells Inversely Correlate With Risk Factors for Coronary Artery Disease
Mariuca Vasa,Stephan Fichtlscherer,Alexandra Aicher,Klaudia Adler,Carmen Urbich,Hans Martin,Andreas M. Zeiher,Stefanie Dimmeler +7 more
TL;DR: Patients with CAD revealed reduced levels and functional impairment of EPCs, which correlated with risk factors for CAD, and hypertension was identified as a major independent predictor for impaired EPC migration.
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Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)
Birgit Assmus,Volker Schächinger,Claudius Teupe,Martina B. Britten,Ralf Lehmann,N. Döbert,Frank Grünwald,Alexandra Aicher,Carmen Urbich,Hans Martin,Dieter Hoelzer,Stefanie Dimmeler,Andreas M. Zeiher +12 more
TL;DR: In patients with AMI, intracoronary infusion of autologous progenitor cells appears to be feasible and safe and may beneficially affect postinfarction remodeling processes.
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Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.
Volker Schächinger,Sandra Erbs,Albrecht Elsässer,Werner Haberbosch,Rainer Hambrecht,Hans Hölschermann,Jiangtao Yu,Roberto Corti,D. G. Mathey,Christian W. Hamm,Tim Suselbeck,Birgit Assmus,Torsten Tonn,Stefanie Dimmeler,Andreas M. Zeiher +14 more
TL;DR: Intracoronary administration of BMC is associated with improved recovery of left ventricular contractile function in patients with acute myocardial infarction and large-scale studies are warranted to examine the potential effects of progenitor-cell administration on morbidity and mortality.