R
Rüdiger Göke
Researcher at University of Marburg
Publications - 96
Citations - 7289
Rüdiger Göke is an academic researcher from University of Marburg. The author has contributed to research in topics: Receptor & Insulin. The author has an hindex of 39, co-authored 95 publications receiving 7056 citations. Previous affiliations of Rüdiger Göke include University of Göttingen & University of Michigan.
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Journal ArticleDOI
Quantitative dissociation of glucose transport stimulation and insulin receptor tyrosine kinase activation in isolated adipocytes with a covalent insulin dimer (B29,B29′-sunberoyl-insulin)
H. G. Joost,Rüdiger Göke,Christoph Schmitz-Salue,Hans Jürgen Steinfelder,Dietrich Brandenburg +4 more
TL;DR: It is concluded that a partial phosphorylation of insulin receptors and a submaximal tyrosine kinase activation are sufficient for full stimulation of glucose transport in the adipocyte and suggested that negative cooperativity of the insulin receptor and activation of its tyrosin kinase require a similar conformational change of the receptor protein.
Journal ArticleDOI
The genomic organization of the human GLP-1 receptor gene.
TL;DR: A comparison of the genomic structure with other related receptor genes indicates that the exon/intron organization is well-conserved among the VIP/ glucagon/secretin receptor family.
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Internalization of glucagon-like peptide-1(7-36)amide in rat insulinoma cells.
TL;DR: HLC-supported analysis of cell content after internalization of125I-GLP-1(7–36)amide during a 60-min incubation period at 37°C revealed an elution profile showing two maxima of radioactivity: one represented intact labeled GLP- 1(7-36), the other an intracellular degradation product of the peptide.
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Characterisation of the expression and post-translational processing of the preprotachykinin-I gene and the regulated release of tachykinins by the RINm5F cell-line.
Gerard P. McGregor,Robert Hartel,Hans-Christoph Fehmann,Brigitte Lankat-Buttgereit,Burkhard Göke,Rüdiger Göke,Karlheinz Voigt +6 more
TL;DR: Normal transcription and postranslational processing of the preprotachykinin (PPT)‐I gene and regulated release of substance P and neurokinin A by the rat pancreatic endocrine cell‐line, RINm5F, has been demonstrated, using radioimmunoassays, reversed‐phase (rp)HPLC and Northern blot analysis.
Journal Article
Carbachol priming increases glucose- and glucagon-like peptide-1 (7-36)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas.
TL;DR: The data suggest that in the regulation of postprandial insulin release cholinergic sensitizing effects might be involved which are mediated by muscarinic receptors.