Rüdiger Göke

TL;DR: The data suggest amylin, a secretory product of pancreatic B-cells, as a peptide with approximately strong paracrine effects within the Langerhans islet might be involved in the regulation of glucose homeostasis.

TL;DR: The understanding of GLP‐1 receptor regulation and signal transduction will aid in the discovery of compounds that act as agonists of the GLP•1 receptor for potential use in the treatment of diabetes and will facilitate the understanding of its expression under normal and pathophysiological conditions.

TL;DR: This in vitro studies aimed to characterize the pattern and the kinetics of endoproteolysis of the insulinotropic hormone glucagon-like peptide-1 (GLP-1) and related peptides by native ectopeptidases and found that exendin-4 is several orders of magnitude more stable than GLP- 1 and Ser-8-GLp-1 is especially noteworthy given this peptide's widely reported insulinotropic potency.

TL;DR: Using quantitative in vitro autoradiography, a high density of specific binding sites for GLP-1 was characterized on sections of the posterior pituitary lobe of the rat, revealing high and low affinity binding sites.

TL;DR: Nuclear survivin expression appears to be upregulated during progression of gastroenteropancreatic neuroendocrine tumors, which identifies subgroups in metastatic disease with good (survivin–) or with less favorable prognosis (Survivin+).