R
Rufus S. Day
Researcher at Cross Cancer Institute
Publications - 62
Citations - 5949
Rufus S. Day is an academic researcher from Cross Cancer Institute. The author has contributed to research in topics: DNA repair & DNA. The author has an hindex of 27, co-authored 62 publications receiving 5904 citations. Previous affiliations of Rufus S. Day include Kyoto University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
A cell cycle regulator potentially involved in genesis of many tumor types
Alexander Kamb,Nelleke A. Gruis,Jane Weaver-Feldhaus,Qingyun Liu,Keith D Harshman,Sean V. Tavtigian,Elisabeth Stockert,Rufus S. Day,Bruce E. Johnson,Mark H. Skolnick,Mark H. Skolnick +10 more
TL;DR: Findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.
Journal ArticleDOI
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
Susan P. Lees-Miller,Roseline Godbout,Doug W. Chan,Michael Weinfeld,Rufus S. Day,Geraldine M. Barron,Joan Allalunis-Turner +6 more
TL;DR: The radiosensitive rodent mutant cell line xrs-5 is defective in DNA double-strand break repair and lacks the Ku component of the DNA-activated protein kinase, DNA-PK, which suggests that DNA- PK kinase activity is involved in DNAdouble-stranded break repair.
Journal ArticleDOI
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains
Rufus S. Day,Chuck H. J. Ziolkowski,Dominic A. Scudiero,Sharon A. Meyer,Anthony S. Lubiniecki,Anthony J. Girardi,Sheila M. Galloway,Gaither D. Bynum +7 more
TL;DR: It is reported that Mer− strains are deficient in removing O6-methylguanine (O6-MeG) from their DNA after [Me-14C]MNNG treatment and originate from tumours arising in patients having Mer+ normal fibroblasts.
Journal ArticleDOI
Human tumor cell strains defective in the repair of alkylation damage.
TL;DR: Two human astrocytoma cell strains as defective in the repair of N-methyl-N' -nitro-N-nitrosoguanidine (MNNG) damaged adenovirus 5 are shown to be very sensitive to MNNG-produced killing as measured by colony forming ability, but are normally sensitive to ultraviolet light.
Journal ArticleDOI
Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs.
TL;DR: Two aneuploid cell lines which differ in their inherent sensitivity to ionizing radiation and chemotherapeutic agents were established concurrently from a single tumor specimen obtained from a patient with glioblastoma may prove to provide a useful model system for evaluating the cellular and molecular processes which confer resistance or sensitivity in cancer treatment.