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Nelleke A. Gruis
Researcher at Leiden University Medical Center
Publications - 160
Citations - 13852
Nelleke A. Gruis is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Melanoma & CDKN2A. The author has an hindex of 49, co-authored 159 publications receiving 13080 citations. Previous affiliations of Nelleke A. Gruis include Loyola University Medical Center & Harvard University.
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Journal ArticleDOI
A cell cycle regulator potentially involved in genesis of many tumor types
Alexander Kamb,Nelleke A. Gruis,Jane Weaver-Feldhaus,Qingyun Liu,Keith D Harshman,Sean V. Tavtigian,Elisabeth Stockert,Rufus S. Day,Bruce E. Johnson,Mark H. Skolnick,Mark H. Skolnick +10 more
TL;DR: Findings suggest that MTS1 mutations are involved in tumor formation in a wide range of tissues.
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Analysis of the p16 gene (CDKN2) as a candidate· for the chromosome 9p melanoma susceptibility locus
Alexander Kamb,Donna M Shattuck-Eidens,Rosalind A. Eeles,Rosalind A. Eeles,Qingyun Liu,Nelleke A. Gruis,Nelleke A. Gruis,Wei Ding,Charles E. Hussey,Thanh Tran,Yoshio Miki,Jane Weaver-Feldhaus,Melody McClure,Joanne F. Aitken,David E. Anderson,Wilma Bergman,Rune R. Frants,David E. Goldgar,Adèle C. Green,Robert MacLennan,Nicholas G. Martin,Laurence Meyer,Laurence Meyer,P. Youl,John J. Zone,Mark H. Skolnick,Mark H. Skolnick,Lisa A. Cannon-Albright +27 more
TL;DR: A locus for familial melanoma, MLM, has been mapped within the same interval on chromosome 9p21 as the gene for a putative cell cycle regulator, p16INK4 (CDKN2) MTS1, suggesting that CDKN2 is a good candidate for MLM.
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Geographical Variation in the Penetrance of CDKN2A Mutations for Melanoma
D. Timothy Bishop,Florence Demenais,Alisa M. Goldstein,Wilma Bergman,Julia A. Newton Bishop,Brigitte Bressac-de Paillerets,Agnès Chompret,Paola Ghiorzo,Nelleke A. Gruis,Johan Hansson,Mark Harland,Nicholas K. Hayward,Elizabeth A. Holland,Graham J. Mann,Michela Mantelli,Derek J. Nancarrow,Anton Platz,Margaret A. Tucker +17 more
TL;DR: This study indicates that the penetrance of CDKN2A mutation penetrance varies with melanoma population incidence rates, and suggests that the same factors that affect population incidence of melanoma may also mediate CD KN2A penetrance.
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Genome-wide association study identifies three loci associated with melanoma risk.
D. Timothy Bishop,Florence Demenais,Mark M. Iles,Mark Harland,John C. Taylor,Eve Corda,Eve Corda,Juliette Randerson-Moor,Joanne F. Aitken,Marie-Françoise Avril,Esther Azizi,Bert Bakker,Giovanna Bianchi-Scarrà,Brigitte Bressac-de Paillerets,Donato Calista,Lisa A. Cannon-Albright,Thomas Chin-A-Woeng,Tadeusz Dębniak,Gilli Galore-Haskel,Paola Ghiorzo,Ivo Gut,Johan Hansson,Marko Hočevar,Veronica Höiom,John L. Hopper,Christian Ingvar,Peter A. Kanetsky,Richard F. Kefford,Maria Teresa Landi,Julie Lang,Jan Lubinski,Rona M. MacKie,Josep Malvehy,Graham J. Mann,Nicholas G. Martin,Grant W. Montgomery,Frans A. van Nieuwpoort,Srdjan Novaković,Håkan Olsson,Susana Puig,Marjan M. Weiss,Wilbert van Workum,Diana Zelenika,Kevin M. Brown,Alisa M. Goldstein,Elizabeth M. Gillanders,Anne Boland,Pilar Galan,David E. Elder,Nelleke A. Gruis,Nicholas K. Hayward,G. Mark Lathrop,G. Mark Lathrop,Jennifer H. Barrett,Julia A. Newton Bishop +54 more
TL;DR: Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk.
Journal ArticleDOI
Melanocortin 1 receptor (MC1R) gene variants are associated with an increased risk for cutaneous melanoma which is largely independent of skin type and hair color.
C. Kennedy,Jeanet A.C. ter Huurne,Marjo J.P. Berkhout,Nelleke A. Gruis,Maarten T. Bastiaens,Wilma Bergman,Rein Willemze,Jan Nico Bouwes Bavinck +7 more
TL;DR: In this article, the authors evaluated the relationship of melanocortin 1 receptor gene variants, fair skin, red hair and the development of melanoma in 123 patients with cutaneous melanoma and 385 control subjects.