Rui Hu

TL;DR: The measurements reveal a correlation between the mean current blockade amplitude and the radius of gyration for each protein, and the magnitude of the structural fluctuations, as probed by experiments and simulations, correlates with the ratio of α-helix to β-sheet content.

TL;DR: The results unequivocally demonstrate that nanopore-based measurements reliably probe conformational diversity in native protein ensembles.

TL;DR: Mechanistic insight into laser-induced thinning of low-stress silicon nitride (SiN x) membranes and films is presented and it is found that SiN x can be etched under exposure to light of ∼107 W/cm2 average intensity, with etch rates that are influenced by the supporting electrolyte.

TL;DR: The results show that 1,2-dioleoyl-sn-glycero-3-[phospho-L-serine] (DOPS) small unilamellar vesicles (SUVs) dramatically enhances the aggregation rate of α-Syn while do not alter the aggregation pathway, and an underlying consumption mechanism that the formation of large oligomers consumes small oligomers is found.

TL;DR: Replica-exchange molecular dynamics simulations revealed that addition of an acetyl group at the N-terminus disrupts intermolecular hydrogen bonds, which slows down the initial α-Syn oligomerization.