R
Rui Liang
Researcher at Merck & Co.
Publications - 31
Citations - 1300
Rui Liang is an academic researcher from Merck & Co.. The author has contributed to research in topics: Glucagon receptor & Type 2 Diabetes Mellitus. The author has an hindex of 16, co-authored 30 publications receiving 1118 citations. Previous affiliations of Rui Liang include Princeton University.
Papers
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Journal ArticleDOI
Parallel Synthesis and Screening of a Solid Phase Carbohydrate Library
Rui Liang,Lin Yan,Jennifer Loebach,Min Ge,Yasuhiro Uozumi,Klara Sekanina,Nina Horan,Jeff Gildersleeve,Christopher Thompson,Andri Smith,Kaustav Biswas,W. Clark Still,Daniel Kahne +12 more
TL;DR: The strategy outlined can be used to identify carbohydrate-based ligands for any receptor; however, because the derivatized beads mimic the polyvalent presentation of cell surface carbohydrates, the screen may prove especially valuable for discovering new compounds that bind to proteins participating in cell adhesion.
Journal ArticleDOI
An orally available non-nucleotide STING agonist with antitumor activity
Bo-Sheng Pan,Samanthi A. Perera,Jennifer Piesvaux,Jeremy Presland,Gottfried K. Schroeder,Jared N. Cumming,B. Wesley Trotter,Michael D. Altman,Alexei V. Buevich,Brandon Cash,Saso Cemerski,Wonsuk Chang,Yiping Chen,Peter J. Dandliker,Guo Feng,Andrew M. Haidle,Timothy J. Henderson,James P. Jewell,Ilona Kariv,Ian Knemeyer,Johnny E. Kopinja,Brian M. Lacey,Jason Laskey,Charles A. Lesburg,Rui Liang,Brian Long,Min Lu,Yanhong Ma,Ellen C. Minnihan,Greg O’Donnell,Ryan D. Otte,Laura Price,Larissa Rakhilina,Berengere Sauvagnat,Sharad K. Sharma,Sriram Tyagarajan,Hyun Chong Woo,Daniel F. Wyss,Serena Xu,David Jonathan Bennett,George H. Addona +40 more
TL;DR: A previously unknown compound (MSA-2) that exhibits “closed” STING conformation and antitumor immunity is identified and identified in a phenotypic screen for chemical inducers of interferon-β secretion.
Patent
Cyclic di-nucleotide compounds as sting agonists
Michael D. Altman,Brian M. Andresen,Wonsuk Chang,Matthew Lloyd Childers,Jared N. Cumming,Andrew M. Haidle,Timothy J. Henderson,James P. Jewell,Rui Liang,Jongwon Lim,Hong Liu,Min Lu,Alan B. Northrup,Ryan D. Otte,Tony Siu,Benjamin Wesley Trotter,Quang T. Truong,Shawn P. Walsh,Kake Zhao +18 more
TL;DR: In this article, a class of polycyclic compounds of general formula (II), of general form (II'), or of general condition (II) was defined, which may be useful as inductors of type I interferon production, specifically as STING active agents.
Journal ArticleDOI
Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes.
Yusheng Xiong,Guo Jian,Mari R. Candelore,Rui Liang,Corey Miller,Qing Dallas-Yang,Guoqiang Jiang,Peggy E. McCann,Sajjad A. Qureshi,Xinchun Tong,Shiyao Sherrie Xu,Jackie Shang,Stella H. Vincent,Laurie Tota,Michael Wright,Xiaodong Yang,Bei B. Zhang,James R. Tata,Emma R. Parmee +18 more
TL;DR: Compound 9m blunted glucagon-induced glucose elevation in hGCGR mice and rhesus monkeys and lowered ambient glucose levels in both acute and chronic mouse models.
Journal ArticleDOI
Discovery of novel disaccharide antibacterial agents using a combinatorial library approach.
Michael J. Sofia,Nigel M. Allanson,Nicole T. Hatzenbuhler,Rakesh K. Jain,Ramesh Kakarla,Natan A. Kogan,Rui Liang,Dashan Liu,Domingos J. Silva,Huiming Wang,David Gange,Jan A. Anderson,Anna Chen,Feng Chi,Richard G. Dulina,Buwen Huang,Muthoni G. Kamau,Chunguang Wang,Eugene R. Baizman,Arthur Branstrom,Neil Bristol,Robert D. Goldman,Kiho Han,Clifford B. Longley,Sunita Midha,Helena R. Axelrod +25 more
TL;DR: The solid-phase synthesis of a library of moenomycin disaccharide analogues and the identification of novel antibacterial agents from this library is described.