Alexei V. Buevich

TL;DR: A previously unknown compound (MSA-2) that exhibits “closed” STING conformation and antitumor immunity is identified and identified in a phenotypic screen for chemical inducers of interferon-β secretion.

TL;DR: The LR-HSQMBC NMR experiment can be extended to provide data similar to that afforded by 1,n-ADEQUATE even in sample-limited situations by optimizing responses for very small (n)JCH coupings as opposed to relying on the markedly less sensitive detection of long-range coupled ( 13)C-(13)C homonuclear pairs at natural abundance.

TL;DR: A chemoselective peptide modification method via photocatalytic tryptophan β-position conjugation has been discovered, providing a novel approach toward peptide modifications to support the discovery of new therapeutic peptides, protein labeling and bioconjugation.

TL;DR: The results suggest that PPS experiences a higher degree of correlated motion at pH 6.0 and that electrostatic interactions may be important for inducing correlated motions on the nanosecond timescale in unfolded PPS.

TL;DR: This work has demonstrated that the proposed synergistic approach is an unbiased, reliable, and very efficient structure verification and de novo structure elucidation method that can be applied to difficult structural problems when other experimental methods would be difficult or impossible to use.