M
Min Lu
Researcher at Merck & Co.
Publications - 41
Citations - 1294
Min Lu is an academic researcher from Merck & Co.. The author has contributed to research in topics: Enantioselective synthesis & Organocatalysis. The author has an hindex of 17, co-authored 41 publications receiving 1062 citations. Previous affiliations of Min Lu include University of California, San Diego & Nanyang Technological University.
Papers
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Journal ArticleDOI
An orally available non-nucleotide STING agonist with antitumor activity
Bo-Sheng Pan,Samanthi A. Perera,Jennifer Piesvaux,Jeremy Presland,Gottfried K. Schroeder,Jared N. Cumming,B. Wesley Trotter,Michael D. Altman,Alexei V. Buevich,Brandon Cash,Saso Cemerski,Wonsuk Chang,Yiping Chen,Peter J. Dandliker,Guo Feng,Andrew M. Haidle,Timothy J. Henderson,James P. Jewell,Ilona Kariv,Ian Knemeyer,Johnny E. Kopinja,Brian M. Lacey,Jason Laskey,Charles A. Lesburg,Rui Liang,Brian Long,Min Lu,Yanhong Ma,Ellen C. Minnihan,Greg O’Donnell,Ryan D. Otte,Laura Price,Larissa Rakhilina,Berengere Sauvagnat,Sharad K. Sharma,Sriram Tyagarajan,Hyun Chong Woo,Daniel F. Wyss,Serena Xu,David Jonathan Bennett,George H. Addona +40 more
TL;DR: A previously unknown compound (MSA-2) that exhibits “closed” STING conformation and antitumor immunity is identified and identified in a phenotypic screen for chemical inducers of interferon-β secretion.
Journal ArticleDOI
Chiral Brønsted Acid-Catalyzed Enantioselective α-Hydroxylation of β-Dicarbonyl Compounds
TL;DR: The results disclosed herein considerably extend the substrate scope for the alpha-aminoxylation, allowing expeditious, straightforward, and efficient access to valuable alpha-hydroxy-beta-dicarbonyl compounds with the highest levels of enantiocontrol.
Patent
Cyclic di-nucleotide compounds as sting agonists
Michael D. Altman,Brian M. Andresen,Wonsuk Chang,Matthew Lloyd Childers,Jared N. Cumming,Andrew M. Haidle,Timothy J. Henderson,James P. Jewell,Rui Liang,Jongwon Lim,Hong Liu,Min Lu,Alan B. Northrup,Ryan D. Otte,Tony Siu,Benjamin Wesley Trotter,Quang T. Truong,Shawn P. Walsh,Kake Zhao +18 more
TL;DR: In this article, a class of polycyclic compounds of general formula (II), of general form (II'), or of general condition (II) was defined, which may be useful as inductors of type I interferon production, specifically as STING active agents.
Journal ArticleDOI
Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents.
Kyriacos C. Nicolaou,Min Lu,Sotirios Totokotsopoulos,Philipp Heretsch,Denis Giguère,Ya Ping Sun,David Sarlah,Thu Han Nguyen,Ian Coulter Wolf,Donald F. Smee,Craig W. Day,Selina Bopp,Elizabeth A. Winzeler +12 more
TL;DR: Biological screening of selected synthesized compounds led to the discovery of a number of nanomolar antipoliovirus agents and several low-micromolar anti- Plasmodium falciparum lead compounds.
Journal ArticleDOI
A highly diastereo- and enantioselective synthesis of multisubstituted cyclopentanes with four chiral carbons by the organocatalytic domino Michael-Henry reaction.
TL;DR: Highly functionalized cyclopentanes with four stereogenic carbons including two quaternary stereocenters have been synthesized in excellent yields with complete diastereoselectivity and excellent enantioselectivities by the organocatalyzed asymmetric domino Michael-Henry reaction.