R
Rui Wei
Researcher at Li Ka Shing Faculty of Medicine, University of Hong Kong
Publications - 8
Citations - 40
Rui Wei is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Induced pluripotent stem cell & Medicine. The author has an hindex of 2, co-authored 4 publications receiving 28 citations. Previous affiliations of Rui Wei include Guangzhou Institutes of Biomedicine and Health.
Papers
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Journal ArticleDOI
Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells
Jiayin Yang,Yu Wang,Ting Zhou,Lai-Yung Wong,Xiao Yu Tian,Xueyu Hong,Wing-Hon Lai,Ka-Wing Au,Rui Wei,Liu Yuqing,Lai-Hung Cheng,Guichan Liang,Zhijian Huang,Wenxia Fan,Ping Zhao,Xiwei Wang,David P. Ibañez,Zhiwei Luo,Yingying Li,Xiaofen Zhong,Shuhan Chen,Dongye Wang,Li Li,Liangxue Lai,Baoming Qin,Xichen Bao,Andrew P. Hutchins,Chung-Wah Siu,Yu Huang,Miguel A. Esteban,Hung-Fat Tse +30 more
TL;DR: The iHep models recapitulate clinical observations of higher potency of PCSK9 antibodies compared with statins for reversing the consequences of FH, demonstrating the utility for preclinical testing of new therapies for FH patients.
Journal ArticleDOI
CRISPR-targeted genome editing of human induced pluripotent stem cell-derived hepatocytes for the treatment of Wilson’s disease
Rui Wei,Rui Wei,Wouter K. G. Leclercq,Jiayin Yang,Brian J. Meacham,Chi-Wa Cheng,Chi-Wa Cheng,Wai-In Ho,Wai-In Ho,Na Li,Na Li,Yang Hu,Yang Hu,Xueyu Hong,Fu Jian,Bo Yang,Liu Yuqing,Jiang Lixiang,Wing-Hon Lai,Wing-Hon Lai,Ka-Wing Au,Ka-Wing Au,Wai-Ling Tsang,Yiu-Lam Tse,Yiu-Lam Tse,Kwong-Man Ng,Kwong-Man Ng,Miguel A. Esteban,Hung-Fat Tse +28 more
TL;DR: In this article, a gene-corrected patient-specific induced pluripotent stem cell (iPSC)-derived hepatocytes (iHeps) were used as an autologous cell source for cellular transplantation therapy in Wilson's disease.
Journal ArticleDOI
A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes.
Jiayin Yang,Lai-Yung Wong,Xiao Yu Tian,Rui Wei,Wing-Hon Lai,Ka-Wing Au,Zhiwei Luo,Carl Ward,Wai-In Ho,David P. Ibañez,Hao Liu,Xichen Bao,Baoming Qin,Yu Huang,Miguel A. Esteban,Hung-Fat Tse +15 more
TL;DR: A human liver chimeric mouse model using FH induced pluripotent stem cell (iPSC)-derived hepatocytes (iHeps) that responded to lipid-lowering drugs and recapitulated clinical observations of increased efficacy of PCSK9 antibodies compared to statins could be useful for preclinical testing of new therapies to FH.
Book ChapterDOI
Generation of Human Liver Chimeric Mice and Harvesting of Human Hepatocytes from Mouse Livers.
Journal ArticleDOI
Generation of a human iPSC line GIBHi002-A-2 with a dual-reporter for NKX2-5 using TALENs
Zhou Min,Rui Wei,Yu Jiang,Fu Jian,Liu Yuqing,Bo Yang,Baorong Yu,Yun Lin,Xinru Ran,Wing-Hon Lai,Meng Chu,Yang Hu,Jiayin Yang,Hung-Fat Tse +13 more
TL;DR: In this paper, the authors used the exon 1 coding region of NKX2-5 from a human iPSC line iPSN0003 using TALENs to monitor and optimize cardiac differentiation procedures via the cardiac progenitor cells (CPCs).