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Andrew P. Hutchins
Researcher at Southern University of Science and Technology
Publications - 81
Citations - 3301
Andrew P. Hutchins is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Reprogramming & Gene. The author has an hindex of 28, co-authored 68 publications receiving 2550 citations. Previous affiliations of Andrew P. Hutchins include University of Science and Technology of China & John Innes Centre.
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Journal ArticleDOI
The IL-10/STAT3-mediated anti-inflammatory response: recent developments and future challenges
TL;DR: From the cataloguing of the in vivo genomic targets of STAT3 (the transcription factor downstream of IL-10) to the identification of specific co-factors that endow STAT3 with genomic-binding specificity, and how genomic and computational methods are being used to elucidate the regulatory mechanisms of this essential physiological response in macrophages are reviewed.
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Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling
Mike Clarke,Amanda J. Lohan,Bernard A. Liu,Ilias Lagkouvardos,Scott William Roy,Nikhat Zafar,Claire Bertelli,Christina Schilde,Arash Kianianmomeni,Thomas R. Bürglin,Christian Frech,Bernard Turcotte,Klaus O. Kopec,John M. Synnott,Caleb Choo,Ivan A. Paponov,Aliza Finkler,Chris Soon Heng Tan,Andrew P. Hutchins,Thomas Weinmeier,Thomas Rattei,Jeffery Sc Chu,Gregory Gimenez,Manuel Irimia,Daniel J. Rigden,David A. Fitzpatrick,Jacob Lorenzo-Morales,Alex Bateman,Cheng-Hsun Chiu,Petrus Tang,Peter Hegemann,Hillel Fromm,Didier Raoult,Gilbert Greub,Diego Miranda-Saavedra,Nansheng Chen,Piers Nash,Michael L. Ginger,Matthias Horn,Pauline Schaap,Lis Caler,Brendan J. Loftus +41 more
TL;DR: In this paper, the authors present an analysis of a whole genome assembly of Acanthamoeba castellanii (Ac) the first representative from a solitary freeliving amoebozoan.
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Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm.
Irene Aksoy,Ralf Jauch,Jiaxuan Chen,Mateusz Dyla,Ushashree Divakar,Gireesh K. Bogu,Roy Teo,Calista Keow Leng Ng,Calista Keow Leng Ng,Wishva Herath,Sun Lili,Andrew P. Hutchins,Andrew P. Hutchins,Paul Robson,Paul Robson,Prasanna R. Kolatkar,Prasanna R. Kolatkar,Lawrence W. Stanton,Lawrence W. Stanton,Lawrence W. Stanton +19 more
TL;DR: It is demonstrated here that genomic redistribution of Oct4 by alternative partnering with Sox2 and Sox17 is a fundamental regulatory event of endodermal specification and provides insights in understanding cell fate transcriptional regulation by highlighting the direct link between the DNA sequence of an enhancer and a developmental outcome.
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Chromatin Accessibility Dynamics during iPSC Reprogramming
Dongwei Li,Jing Liu,Xuejie Yang,Chunhua Zhou,Jing Guo,Chuman Wu,Yue Qin,Lin Guo,Jiangping He,Shenyong Yu,He Liu,Xiaoshan Wang,Fang Wu,Junqi Kuang,Andrew P. Hutchins,Jiekai Chen,Duanqing Pei +16 more
TL;DR: In this article, ATAC-seq profiling of MEFs expressing Oct4-Sox2-Klf4 (OSK) reveals dynamic changes in chromatin states shifting from open to closed (OC) and closed to open (CO), with an initial burst of OC and an ending surge of CO.
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The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters.
Xichen Bao,Haitao Wu,Xihua Zhu,Xihua Zhu,Xiangpeng Guo,Xiangpeng Guo,Andrew P. Hutchins,Zhiwei Luo,Zhiwei Luo,Hong Song,Yongqiang Chen,Keyu Lai,Menghui Yin,Lingxiao Xu,Liang Zhou,Jiekai Chen,Dongye Wang,Baoming Qin,Jon Frampton,Hung-Fat Tse,Duanqing Pei,Huating Wang,Biliang Zhang,Miguel A. Esteban +23 more
TL;DR: Insight is provided into the role of lncRNAs in reprogramming and a novel link between p53 and heterochromatin regulation is established and established.